Mouse Gene Etv5 (ENSMUST00000079601.12) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus ets variant 5 (Etv5), transcript variant 2, mRNA. (from RefSeq NM_023794)
Gencode Transcript: ENSMUST00000079601.12
Gencode Gene: ENSMUSG00000013089.15
Transcript (Including UTRs)
   Position: mm10 chr16:22,381,309-22,439,719 Size: 58,411 Total Exon Count: 13 Strand: -
Coding Region
   Position: mm10 chr16:22,383,470-22,436,482 Size: 53,013 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:22,381,309-22,439,719)mRNA (may differ from genome)Protein (510 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ETV5_MOUSE
DESCRIPTION: RecName: Full=ETS translocation variant 5;
FUNCTION: Binds to DNA sequences containing the consensus nucleotide core sequence GGAA (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the ETS family.
SIMILARITY: Contains 1 ETS DNA-binding domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D016604 Aflatoxin B1
  • D001564 Benzo(a)pyrene
  • D016572 Cyclosporine
  • D008767 Methylmercury Compounds
  • D013749 Tetrachlorodibenzodioxin
  • C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)
  • C032668 1-nitropyrene
  • C010914 2,4-diaminotoluene
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C017906 3-dinitrobenzene
          more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -122.70281-0.437 Picture PostScript Text
3' UTR -698.602161-0.323 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000418 - Ets
IPR006715 - ETS_PEA3_N
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00178 - Ets-domain
PF04621 - PEA3 subfamily ETS-domain transcription factor N terminal domain

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q9CXC9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007274 neuromuscular synaptic transmission
GO:0007626 locomotory behavior
GO:0030154 cell differentiation
GO:0034599 cellular response to oxidative stress
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048133 male germ-line stem cell asymmetric division
GO:0050807 regulation of synapse organization
GO:0060252 positive regulation of glial cell proliferation
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0071340 skeletal muscle acetylcholine-gated channel clustering

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane


-  Descriptions from all associated GenBank mRNAs
  AK168881 - Mus musculus 17 days embryo kidney cDNA, RIKEN full-length enriched library, clone:I920062G11 product:ETS-related transcription factor, full insert sequence.
AK164091 - Mus musculus 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530010N03 product:ETS-related transcription factor, full insert sequence.
BC034680 - Mus musculus ets variant gene 5, mRNA (cDNA clone MGC:28414 IMAGE:4036564), complete cds.
AK049234 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:C330015H07 product:ETS-RELATED TRANSCRIPTION FACTOR, full insert sequence.
AK080674 - Mus musculus 10 days neonate cortex cDNA, RIKEN full-length enriched library, clone:A830076C14 product:ETS-RELATED TRANSCRIPTION FACTOR homolog [Mus musculus], full insert sequence.
AK031452 - Mus musculus 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030434I18 product:ETS-RELATED TRANSCRIPTION FACTOR homolog [Mus musculus], full insert sequence.
AK018368 - Mus musculus 16 days embryo lung cDNA, RIKEN full-length enriched library, clone:8430401F14 product:ETS-RELATED TRANSCRIPTION FACTOR homolog [Mus musculus], full insert sequence.
AY004174 - Mus musculus ets-related transcription factor (Etv5) mRNA, complete cds.
BC039044 - Mus musculus ets variant gene 5, mRNA (cDNA clone IMAGE:4948650), partial cds.
AK003461 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110005E01 product:ets-related transcription factor, full insert sequence.
AK191636 - Mus musculus cDNA, clone:Y1G0106H23, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000051229, based on BLAT search.
AK193204 - Mus musculus cDNA, clone:Y1G0111G21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000051229, based on BLAT search.
AK219366 - Mus musculus cDNA, clone:Y2G0148D23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000051229, based on BLAT search.
AK183584 - Mus musculus cDNA, clone:Y0G0126H03, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000051229, based on BLAT search.
AK205269 - Mus musculus cDNA, clone:Y2G0101D01, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000051229, based on BLAT search.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
m_IL12Pathway - IL12 and Stat4 Dependent Signaling Pathway in Th1 Development

-  Other Names for This Gene
  Alternate Gene Symbols: ETV5_MOUSE, NM_023794, Q3TG49, Q8C0F3, Q9CXC9, Q9JHB1, uc007yse.1, uc007yse.2
UCSC ID: uc007yse.2
RefSeq Accession: NM_023794
Protein: Q9CXC9 (aka ETV5_MOUSE)
CCDS: CCDS37299.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.