Mouse Gene Tmprss15 (ENSMUST00000023566.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus transmembrane protease, serine 15 (Tmprss15), transcript variant 1, mRNA. (from RefSeq NM_008941) RefSeq Summary (NM_008941): This gene encodes an enzyme that proteolytically activates the pancreatic proenzyme trypsinogen, converting it into trypsin. The encoded protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]. Gencode Transcript: ENSMUST00000023566.10 Gencode Gene: ENSMUSG00000022857.13 Transcript (Including UTRs) Position: mm10 chr16:78,953,008-79,091,092 Size: 138,085 Total Exon Count: 28 Strand: - Coding Region Position: mm10 chr16:78,953,800-79,090,917 Size: 137,118 Coding Exon Count: 28
ID:ENTK_MOUSE DESCRIPTION: RecName: Full=Enteropeptidase; EC=3.4.21.9; AltName: Full=Enterokinase; AltName: Full=Serine protease 7; AltName: Full=Transmembrane protease serine 15; Contains: RecName: Full=Enteropeptidase non-catalytic heavy chain; Contains: RecName: Full=Enteropeptidase catalytic light chain; FUNCTION: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (By similarity). CATALYTIC ACTIVITY: Activation of trypsinogen by selective cleavage of 6-Lys-|-Ile-7 bond. SUBUNIT: Heterodimer of a catalytic (light) chain and a multidomain (heavy) chain linked by a disulfide bond (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Probable). PTM: The chains are derived from a single precursor that is cleaved by a trypsin-like protease (By similarity). SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 2 CUB domains. SIMILARITY: Contains 2 LDL-receptor class A domains. SIMILARITY: Contains 1 MAM domain. SIMILARITY: Contains 1 peptidase S1 domain. SIMILARITY: Contains 1 SEA domain. SIMILARITY: Contains 1 SRCR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P97435
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.