Mouse Gene Jam2 (ENSMUST00000114195.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus junction adhesion molecule 2 (Jam2), mRNA. (from RefSeq NM_023844)
Gencode Transcript: ENSMUST00000114195.7
Gencode Gene: ENSMUSG00000053062.16
Transcript (Including UTRs)
Position: mm10 chr16:84,774,123-84,825,928 Size: 51,806 Total Exon Count: 10 Strand: +
Coding Region
Position: mm10 chr16:84,774,487-84,822,819 Size: 48,333 Coding Exon Count: 10
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: JAM2_MOUSE
DESCRIPTION: RecName: Full=Junctional adhesion molecule B; Short=JAM-B; AltName: Full=Junctional adhesion molecule 2; Short=JAM-2; AltName: Full=Vascular endothelial junction-associated molecule; Short=VE-JAM; AltName: CD_antigen=CD322; Flags: Precursor;
FUNCTION: May play a role in the processes of lymphocyte homing to secondary lymphoid organs (By similarity).SUBUNIT: Interacts with JAM3 (By similarity).SUBCELLULAR LOCATION: Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.SIMILARITY: Belongs to the immunoglobulin superfamily.SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR013106 - Ig_V-set
Pfam Domains: PF00047 - Immunoglobulin domain
PF07679 - Immunoglobulin I-set domain
PF07686 - Immunoglobulin V-set domain
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain
SCOP Domains: 48726 - Immunoglobulin
ModBase Predicted Comparative 3D Structure on Q9JI59
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC028778 - Mus musculus junction adhesion molecule 2, mRNA (cDNA clone MGC:41518 IMAGE:1195543), complete cds.AJ291757 - Mus musculus mRNA for junctional adhesion molecule-3, (JAM-3 gene).AK010826 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:2410167M24 product:junction cell adhesion molecule 2, full insert sequence.AK013914 - Mus musculus 13 days embryo head cDNA, RIKEN full-length enriched library, clone:3100002C20 product:junction cell adhesion molecule 2, full insert sequence.AK010616 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:2410030G21 product:junction cell adhesion molecule 2, full insert sequence.AK045095 - Mus musculus 9.5 days embryo parthenogenote cDNA, RIKEN full-length enriched library, clone:B130032E13 product:junction cell adhesion molecule 2, full insert sequence.AK078128 - Mus musculus adult male medulla oblongata cDNA, RIKEN full-length enriched library, clone:6330541C23 product:junction cell adhesion molecule 2, full insert sequence.AF255911 - Mus musculus vascular endothelial junction-associated molecule mRNA, complete cds.AK028757 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732454B13 product:junction cell adhesion molecule 2, full insert sequence.AK153636 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630028I07 product:junction adhesion molecule 2, full insert sequence.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A6X955, JAM2_MOUSE, NM_023844, Q8C5K9, Q8CE95, Q9JI59, uc007ztg.1, uc007ztg.2, uc007ztg.3, uc007ztg.4, VejamUCSC ID: uc007ztg.4RefSeq Accession: NM_023844
Protein: Q9JI59
(aka JAM2_MOUSE)
CCDS: CCDS37381.1
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.