Mouse Gene Gng13 (ENSMUST00000172002.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus guanine nucleotide binding protein (G protein), gamma 13 (Gng13), transcript variant 1, mRNA. (from RefSeq NM_022422)
Gencode Transcript: ENSMUST00000172002.7
Gencode Gene: ENSMUSG00000025739.13
Transcript (Including UTRs)
   Position: mm10 chr17:25,717,171-25,719,406 Size: 2,236 Total Exon Count: 3 Strand: +
Coding Region
   Position: mm10 chr17:25,718,701-25,719,032 Size: 332 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:25,717,171-25,719,406)mRNA (may differ from genome)Protein (67 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GBG13_MOUSE
DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13; Flags: Precursor;
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
SIMILARITY: Belongs to the G protein gamma family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.30141-0.307 Picture PostScript Text
3' UTR -101.30374-0.271 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015898 - G-protein_gamma-like_dom

Pfam Domains:
PF00631 - GGL domain

SCOP Domains:
48670 - Transducin (heterotrimeric G protein), gamma chain

ModBase Predicted Comparative 3D Structure on Q9JMF3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0031681 G-protein beta-subunit binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0050909 sensory perception of taste

Cellular Component:
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite


-  Descriptions from all associated GenBank mRNAs
  LF200956 - JP 2014500723-A/8459: Polycomb-Associated Non-Coding RNAs.
AK018778 - Mus musculus adult male cerebellum cDNA, RIKEN full-length enriched library, clone:1500031D04 product:guanine nucleotide binding protein 13, gamma, full insert sequence.
AY029485 - Mus musculus G protein gamma subunit 13 mRNA, complete cds.
AB030194 - Mus musculus mRNA for G gamma protein, complete cds, clone:2-35.
BC048431 - Mus musculus guanine nucleotide binding protein (G protein), gamma 13, mRNA (cDNA clone MGC:58102 IMAGE:6601662), complete cds.
BC059712 - Mus musculus guanine nucleotide binding protein (G protein), gamma 13, mRNA (cDNA clone MGC:74069 IMAGE:6544762), complete cds.
LF200958 - JP 2014500723-A/8461: Polycomb-Associated Non-Coding RNAs.
MA436533 - JP 2018138019-A/8459: Polycomb-Associated Non-Coding RNAs.
MA436535 - JP 2018138019-A/8461: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04062 - Chemokine signaling pathway
mmu04742 - Taste transduction

Reactome (by CSHL, EBI, and GO)

Protein Q9JMF3 (Reactome details) participates in the following event(s):

R-MMU-6814418 PDCL promotes formation of G-beta:G-gamma heterodimers
R-MMU-825631 Glucagon:GCGR mediates GTP-GDP exchange
R-MMU-167433 G-protein beta-gamma subunits rebind the alpha-GDP subunit
R-MMU-392295 Gbeta:gamma recruits PI3K gamma
R-MMU-398040 Gbeta:gamma activation of PLC beta
R-MMU-750988 Inactive G alpha (z) reassociates with G beta:gamma
R-MMU-750993 Inactive G alpha (q) reassociates with G beta:gamma
R-MMU-751001 Inactive G alpha (i) reassociates with G beta:gamma
R-MMU-751013 Inactive G alpha (s) reassociates with G beta:gamma
R-MMU-751039 Inactive G alpha (12/13) reassociates with G beta:gamma
R-MMU-112271 The receptor:G-protein complex dissociates
R-MMU-392202 Dissociation of the P2Y purinoceptor 12:Gi complex
R-MMU-397835 Dissociation of the PAR:Gq complex
R-MMU-397891 Dissociation of the PAR:G12/13 complex
R-MMU-418576 Dissociation of the P2Y purinoceptor 1:Gq complex
R-MMU-428752 Dissociation of the TP:Gq complex
R-MMU-428918 Dissociation of the TP:G13 complex
R-MMU-744886 The Ligand:GPCR:Gs complex dissociates
R-MMU-749452 The Ligand:GPCR:Gq complex dissociates
R-MMU-749454 The Ligand:GPCR:Gi complex dissociates
R-MMU-751019 The Ligand:GPCR:G12/13 complex dissociates
R-MMU-751024 The Ligand:GPCR:Gz complex dissociates
R-MMU-3965447 G-protein subunits dissociate from WNT:FZD complex
R-MMU-8982640 G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)
R-MMU-8850560 G-protein alpha releases G-protein heterotrimer from PDCL
R-MMU-400097 G-beta:G-gamma inhibits Adenylate cyclase
R-MMU-400037 Gi,Go Heterotrimeric G-protein complex dissociates
R-MMU-422320 Heterotrimeric G(s) complex dissociates
R-NUL-4551534 RFzd binds trimeric G-proteins
R-MMU-428909 Activated TP receptor binds G-protein G13
R-MMU-396996 Thrombin-activated PAR binds G-protein Gq
R-MMU-428749 Activated TP receptor binds G-proten Gq
R-MMU-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-MMU-167408 The high affinity receptor complex binds to G-protein
R-MMU-392852 Activated prostacyclin receptor binds G-protein Gs
R-MMU-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-MMU-392187 Activated P2Y purinoceptor 12 binds G-protein Gi
R-MMU-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-MMU-500717 Activation of GRIK3 homomer
R-MMU-8982637 Opsins binds G alpha-t
R-MMU-749446 Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
R-MMU-3965444 WNT:FZD complex promotes G-protein nucleotide exchange
R-MMU-167429 The receptor:G-protein complex binds GTP
R-MMU-167419 The receptor:G-protein complex releases GDP
R-MMU-381612 Glucagon-like Peptide-1 Receptor (GLP1R) binds Glucagon-like peptide-1
R-MMU-400092 Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins
R-MMU-751027 Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13
R-MMU-428917 G13 activation by TP receptor
R-MMU-114558 Gq activation by PAR
R-MMU-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-MMU-428750 Gq activation by TP receptor
R-MMU-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-MMU-392870 Gs activation by prostacyclin receptor
R-MMU-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-MMU-392195 Gi activation by P2Y purinoceptor 12
R-MMU-392300 G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
R-MMU-398193 PLC beta-mediated PIP2 hydrolysis
R-MMU-420883 Opsins act as GEFs for G alpha-t
R-MMU-749453 Liganded Gz-activating GPCR acts as a GEF for Gz
R-MMU-432195 AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP
R-MMU-114552 G12/13 activation by PAR
R-MMU-751029 Liganded G12/13-activating GPCR acts as a GEF for G12/13
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
R-MMU-163359 Glucagon signaling in metabolic regulation
R-MMU-202040 G-protein activation
R-MMU-392451 G beta:gamma signalling through PI3Kgamma
R-MMU-418217 G beta:gamma signalling through PLC beta
R-MMU-4086398 Ca2+ pathway
R-MMU-418597 G alpha (z) signalling events
R-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-418555 G alpha (s) signalling events
R-MMU-416482 G alpha (12/13) signalling events
R-MMU-392170 ADP signalling through P2Y purinoceptor 12
R-MMU-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-MMU-418592 ADP signalling through P2Y purinoceptor 1
R-MMU-428930 Thromboxane signalling through TP receptor
R-MMU-390466 Chaperonin-mediated protein folding
R-MMU-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-MMU-163685 Energy Metabolism
R-MMU-392851 Prostacyclin signalling through prostacyclin receptor
R-MMU-500657 Presynaptic function of Kainate receptors
R-MMU-111885 Opioid Signalling
R-MMU-397795 G-protein beta:gamma signalling
R-MMU-3858494 Beta-catenin independent WNT signaling
R-MMU-388396 GPCR downstream signalling
R-MMU-392518 Signal amplification
R-MMU-76002 Platelet activation, signaling and aggregation
R-MMU-391251 Protein folding
R-MMU-420092 Glucagon-type ligand receptors
R-MMU-422356 Regulation of insulin secretion
R-MMU-445717 Aquaporin-mediated transport
R-MMU-1430728 Metabolism
R-MMU-418346 Platelet homeostasis
R-MMU-451326 Activation of kainate receptors upon glutamate binding
R-MMU-195721 Signaling by WNT
R-MMU-372790 Signaling by GPCR
R-MMU-109582 Hemostasis
R-MMU-392499 Metabolism of proteins
R-MMU-373080 Class B/2 (Secretin family receptors)
R-MMU-382551 Transport of small molecules
R-MMU-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-MMU-162582 Signal Transduction
R-MMU-500792 GPCR ligand binding
R-MMU-112315 Transmission across Chemical Synapses
R-MMU-112316 Neuronal System

-  Other Names for This Gene
  Alternate Gene Symbols: GBG13_MOUSE, NM_022422, Q9JMF3, uc008bbi.1, uc008bbi.2, uc008bbi.3
UCSC ID: uc008bbi.3
RefSeq Accession: NM_022422
Protein: Q9JMF3 (aka GBG13_MOUSE or GBGD_MOUSE)
CCDS: CCDS37503.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.