ID:RFIP3_MOUSE DESCRIPTION: RecName: Full=Rab11 family-interacting protein 3; Short=FIP3-Rab11; Short=Rab11-FIP3; FUNCTION: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. SUBUNIT: Homodimer. Forms a complex with Rab11 (RAB11A or RAB11B) and ARF6. Interacts with RAB11A; the interaction is direct. Interacts with RAB11B, RAB25 and RAB11FIP4. Interacts with ARF6. Interacts with RACGAP1/MgcRacGAP; interaction takes place during late stage of cytokinesis and is required for recruitment to the midbody. Interacts with EXOC7 (By similarity). Interacts with ASAP1. SUBCELLULAR LOCATION: Recycling endosome membrane; Peripheral membrane protein (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Cleavage furrow (By similarity). Midbody (By similarity). Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission. Interaction with Rab11 mediates localization to endosomes. Interaction with ARF6 mediates localization to the midbody (By similarity). DOMAIN: The RBD-FIP domain mediates the interaction with Rab11 (RAB11A or RAB11B) (By similarity). SIMILARITY: Contains 2 EF-hand domains. SIMILARITY: Contains 1 FIP-RBD domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 140591 - Type III secretion system domain 63411 - LuxS/MPP-like metallohydrolase 57959 - Leucine zipper domain 144270 - Eferin C-derminal domain-like
ModBase Predicted Comparative 3D Structure on Q8CHD8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04144 - Endocytosis
Reactome (by CSHL, EBI, and GO)
Protein Q8CHD8 (Reactome details) participates in the following event(s):
R-MMU-5620921 ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex R-MMU-5623513 ASAP1 stimulates GTPase activity of ARF4 R-MMU-5623519 RAB3IP and RAB8A bind to the ciliary targeting complex R-MMU-5623521 RAB3IP stimulates nucleotide exchange on RAB8A R-MMU-5623524 The exocyst complex binds to RAB3IP in the ciliary targeting complex R-MMU-5620916 VxPx cargo-targeting to cilium R-MMU-5620920 Cargo trafficking to the periciliary membrane R-MMU-5617833 Cilium Assembly R-MMU-1852241 Organelle biogenesis and maintenance
US Server
