ID:BRD4_MOUSE DESCRIPTION: RecName: Full=Bromodomain-containing protein 4; AltName: Full=Mitotic chromosome-associated protein; Short=MCAP; FUNCTION: Plays a role in a process governing chromosomal dynamics during mitosis. SUBUNIT: Associated with chromosomes during mitosis. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 2 bromo domains. SIMILARITY: Contains 1 NET domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ESU6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000993 RNA polymerase II core binding GO:0002039 p53 binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0004672 protein kinase activity GO:0004674 protein serine/threonine kinase activity GO:0005515 protein binding GO:0008022 protein C-terminus binding GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity GO:0034211 GTP-dependent protein kinase activity GO:0070577 lysine-acetylated histone binding GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding
Biological Process: GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0001833 inner cell mass cell proliferation GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006468 protein phosphorylation GO:0007059 chromosome segregation GO:0010971 positive regulation of G2/M transition of mitotic cell cycle GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043388 positive regulation of DNA binding GO:0043983 histone H4-K12 acetylation GO:0044154 histone H3-K14 acetylation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046777 protein autophosphorylation GO:0050727 regulation of inflammatory response GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain
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