Mouse Gene Flot1 (ENSMUST00000001569.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus flotillin 1 (Flot1), mRNA. (from RefSeq NM_008027)
Gencode Transcript: ENSMUST00000001569.14
Gencode Gene: ENSMUSG00000059714.13
Transcript (Including UTRs)
   Position: mm10 chr17:35,823,230-35,832,791 Size: 9,562 Total Exon Count: 13 Strand: +
Coding Region
   Position: mm10 chr17:35,823,821-35,832,539 Size: 8,719 Coding Exon Count: 12 

Page IndexSequence and LinksPrimersCTDRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:35,823,230-35,832,791)mRNA (may differ from genome)Protein (428 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -138.00286-0.483 Picture PostScript Text
3' UTR -70.70252-0.281 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001107 - Band_7

Pfam Domains:
PF01145 - SPFH domain / Band 7 family
PF15975 - Flotillin

SCOP Domains:
117892 - Band 7/SPFH domain

ModBase Predicted Comparative 3D Structure on Q540I4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
      
      
 RGDEnsemblEnsembl  
 Protein Sequence Protein Sequence  
 Alignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0035255 ionotropic glutamate receptor binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0001765 membrane raft assembly
GO:0001819 positive regulation of cytokine production
GO:0001934 positive regulation of protein phosphorylation
GO:0002090 regulation of receptor internalization
GO:0007409 axonogenesis
GO:0022617 extracellular matrix disassembly
GO:0032092 positive regulation of protein binding
GO:0032226 positive regulation of synaptic transmission, dopaminergic
GO:0032728 positive regulation of interferon-beta production
GO:0033227 dsRNA transport
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034976 response to endoplasmic reticulum stress
GO:0035023 regulation of Rho protein signal transduction
GO:0044854 plasma membrane raft assembly
GO:0045807 positive regulation of endocytosis
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0050821 protein stabilization
GO:0051260 protein homooligomerization
GO:0060355 positive regulation of cell adhesion molecule production
GO:0070528 protein kinase C signaling
GO:0071360 cellular response to exogenous dsRNA
GO:0072659 protein localization to plasma membrane
GO:1901741 positive regulation of myoblast fusion
GO:1901890 positive regulation of cell junction assembly
GO:1903044 protein localization to membrane raft
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin

Cellular Component:
GO:0001931 uropod
GO:0005768 endosome
GO:0005769 early endosome
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005911 cell-cell junction
GO:0005913 cell-cell adherens junction
GO:0008180 COP9 signalosome
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016600 flotillin complex
GO:0030027 lamellipodium
GO:0030864 cortical actin cytoskeleton
GO:0031410 cytoplasmic vesicle
GO:0034451 centriolar satellite
GO:0042383 sarcolemma
GO:0044291 cell-cell contact zone
GO:0044853 plasma membrane raft
GO:0045121 membrane raft


-  Descriptions from all associated GenBank mRNAs
  AK150692 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830013M04 product:flotillin 1, full insert sequence.
BC004647 - Mus musculus flotillin 1, mRNA (cDNA clone MGC:5868 IMAGE:3158071), complete cds.
AY167925 - Mus musculus lipid raft protein flotillin-1 (Flot1) mRNA, complete cds.
U90435 - Mus musculus flotillin mRNA, complete cds.
AK150827 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830015L22 product:flotillin 1, full insert sequence.
AK167323 - Mus musculus 13 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530004J16 product:flotillin 1, full insert sequence.
AF145044 - Mus musculus cavatellin-1 mRNA, complete cds.
AK181092 - Mus musculus cDNA, clone:Y0G0116O14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070610, based on BLAT search.
AK219942 - Mus musculus cDNA, clone:Y2G0150D10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070610, based on BLAT search.
AK202818 - Mus musculus cDNA, clone:Y1G0142M17, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070610, based on BLAT search.
AK188620 - Mus musculus cDNA, clone:Y0G0145O18, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000070610, based on BLAT search.
AK190295 - Mus musculus cDNA, clone:Y1G0102F06, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001569, based on BLAT search.
AK178956 - Mus musculus cDNA, clone:Y0G0108I01, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001569, based on BLAT search.
AK200487 - Mus musculus cDNA, clone:Y1G0134L13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001569, based on BLAT search.
AK216334 - Mus musculus cDNA, clone:Y2G0138A07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001569, based on BLAT search.
AK210442 - Mus musculus cDNA, clone:Y2G0118G23, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001569, based on BLAT search.
AK215579 - Mus musculus cDNA, clone:Y2G0135H23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001569, based on BLAT search.
AK216913 - Mus musculus cDNA, clone:Y2G0140A08, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000001569, based on BLAT search.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04910 - Insulin signaling pathway

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_19908, NM_008027, Q540I4, Q540I4_MOUSE, uc008cip.1, uc008cip.2
UCSC ID: uc008cip.2
RefSeq Accession: NM_008027
Protein: Q540I4 CCDS: CCDS28705.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.