Mouse Gene H2-T22 (ENSMUST00000058801.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Belongs to the MHC class I family. (from UniProt Q9BCZ1)
Gencode Transcript: ENSMUST00000058801.14
Gencode Gene: ENSMUSG00000056116.18
Transcript (Including UTRs)
   Position: mm10 chr17:36,038,407-36,042,690 Size: 4,284 Total Exon Count: 9 Strand: -
Coding Region
   Position: mm10 chr17:36,038,751-36,042,426 Size: 3,676 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:36,038,407-36,042,690)mRNA (may differ from genome)Protein (344 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q9BCZ1_MOUSE
DESCRIPTION: SubName: Full=H2-T22 protein; SubName: Full=Protein H2-T22;
SIMILARITY: Belongs to the MHC class I family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.20155-0.279 Picture PostScript Text
3' UTR -101.20344-0.294 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003006 - Ig/MHC_CS
IPR003597 - Ig_C1-set
IPR011161 - MHC_I-like_Ag-recog
IPR011162 - MHC_I/II-like_Ag-recog
IPR001039 - MHC_I_a_a1/a2

Pfam Domains:
PF00129 - Class I Histocompatibility antigen, domains alpha 1 and 2
PF07654 - Immunoglobulin C1-set domain

SCOP Domains:
48726 - Immunoglobulin
54452 - MHC antigen-recognition domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1YPZ - X-ray


ModBase Predicted Comparative 3D Structure on Q9BCZ1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
      
      
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC044208 - Mus musculus histocompatibility 2, T region locus 9, mRNA (cDNA clone MGC:49483 IMAGE:5036676), complete cds.
AK162874 - Mus musculus adult male hypothalamus cDNA, RIKEN full-length enriched library, clone:A230075F09 product:histocompatibility 2, T region locus 22, full insert sequence.
BC003819 - Mus musculus histocompatibility 2, T region locus 22, mRNA (cDNA clone MGC:6180 IMAGE:3484613), complete cds.
AB359229 - Mus musculus H2-T22 mRNA for MHC classIb T22, complete cds.
M35243 - Mouse MHC class I H2-TL-27-129 mRNA (b haplotype), complete cds.
M35247 - Mouse MHC class I H2-TL-T17-c mRNA (d haplotype), complete cds.
M35248 - Mouse MHC class I H2-TL-T9-c mRNA (d haplotype), complete cds.
M35245 - Mouse MHC class I H2-TL-27-b mRNA (b haplotype), complete cds.
AK133985 - Mus musculus 8 days embryo whole body cDNA, RIKEN full-length enriched library, clone:5730592F10 product:histocompatibility 2, T region locus 9, full insert sequence.
AK161744 - Mus musculus adult male thymus cDNA, RIKEN full-length enriched library, clone:5830440O13 product:histocompatibility 2, T region locus 22, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04144 - Endocytosis
mmu04145 - Phagosome
mmu04514 - Cell adhesion molecules (CAMs)
mmu04612 - Antigen processing and presentation
mmu04650 - Natural killer cell mediated cytotoxicity
mmu04940 - Type I diabetes mellitus
mmu05320 - Autoimmune thyroid disease
mmu05330 - Allograft rejection
mmu05332 - Graft-versus-host disease
mmu05416 - Viral myocarditis

-  Other Names for This Gene
  Alternate Gene Symbols: BC003819, Q9BCZ1, Q9BCZ1_MOUSE, uc008cjv.1, uc008cjv.2, uc008cjv.3
UCSC ID: uc008cjv.3
RefSeq Accession: NM_001347382
Protein: Q9BCZ1 CCDS: CCDS84308.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.