Mouse Gene Myom1 (ENSMUST00000179759.2) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus myomesin 1 (Myom1), transcript variant 2, mRNA. (from RefSeq NM_001083934)
Gencode Transcript: ENSMUST00000179759.2
Gencode Gene: ENSMUSG00000024049.15
Transcript (Including UTRs)
   Position: mm10 chr17:71,019,560-71,126,856 Size: 107,297 Total Exon Count: 37 Strand: +
Coding Region
   Position: mm10 chr17:71,022,875-71,126,369 Size: 103,495 Coding Exon Count: 36 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:71,019,560-71,126,856)mRNA (may differ from genome)Protein (1569 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MYOM1_MOUSE
DESCRIPTION: RecName: Full=Myomesin-1; AltName: Full=Myomesin family member 1; AltName: Full=Skelemin;
FUNCTION: May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. May also contact myosin filaments. Also binds beta-integrins.
SUBUNIT: Interacts with TTN/titin and PNKD (By similarity).
TISSUE SPECIFICITY: Muscle.
SIMILARITY: Contains 5 fibronectin type-III domains.
SIMILARITY: Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.40119-0.339 Picture PostScript Text
3' UTR -157.00487-0.322 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003961 - Fibronectin_type3
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2

Pfam Domains:
PF00041 - Fibronectin type III domain
PF07679 - Immunoglobulin I-set domain
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin
49265 - Fibronectin type III
49313 - Cadherin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2JTD - NMR


ModBase Predicted Comparative 3D Structure on Q62234
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005200 structural constituent of cytoskeleton
GO:0008307 structural constituent of muscle
GO:0019900 kinase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0051015 actin filament binding
GO:0051371 muscle alpha-actinin binding
GO:0097493 structural molecule activity conferring elasticity

Biological Process:
GO:0002074 extraocular skeletal muscle development
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007015 actin filament organization
GO:0010628 positive regulation of gene expression
GO:0010737 protein kinase A signaling
GO:0045214 sarcomere organization
GO:0050714 positive regulation of protein secretion
GO:0071688 striated muscle myosin thick filament assembly

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005859 muscle myosin complex
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0031430 M band
GO:0032982 myosin filament


-  Descriptions from all associated GenBank mRNAs
  AJ012072 - Mus musculus mRNA for myomesin/skelemin.
Z22866 - M.musculus skelemin mRNA, complete CDS.
AK052539 - Mus musculus 13 days embryo lung cDNA, RIKEN full-length enriched library, clone:D430047A17 product:myomesin 1, full insert sequence.
BC060378 - Mus musculus myomesin 1, mRNA (cDNA clone MGC:68165 IMAGE:4980452), complete cds.
AK143360 - Mus musculus 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330015F11 product:myomesin 1, full insert sequence.
AK084911 - Mus musculus 13 days embryo lung cDNA, RIKEN full-length enriched library, clone:D430010I09 product:myomesin 1, full insert sequence.
AK041025 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530063G14 product:myomesin 1, full insert sequence.
AK133524 - Mus musculus 11 days pregnant adult female ovary and uterus cDNA, RIKEN full-length enriched library, clone:5033420K20 product:myomesin 1, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: MYOM1_MOUSE, NM_001083934, Q546T8, Q62234, Q6PAC0, uc008dly.1, uc008dly.2
UCSC ID: uc008dly.2
RefSeq Accession: NM_001083934
Protein: Q62234 (aka MYOM1_MOUSE or MYM1_MOUSE)
CCDS: CCDS50176.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.