Mouse Gene Slc30a6 (ENSMUST00000024870.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 30 (zinc transporter), member 6 (Slc30a6), transcript variant 2, mRNA. (from RefSeq NM_144798)
Gencode Transcript: ENSMUST00000024870.8
Gencode Gene: ENSMUSG00000024069.14
Transcript (Including UTRs)
   Position: mm10 chr17:74,395,608-74,424,221 Size: 28,614 Total Exon Count: 14 Strand: +
Coding Region
   Position: mm10 chr17:74,395,666-74,423,514 Size: 27,849 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:74,395,608-74,424,221)mRNA (may differ from genome)Protein (460 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZNT6_MOUSE
DESCRIPTION: RecName: Full=Zinc transporter 6; Short=ZnT-6; AltName: Full=Solute carrier family 30 member 6;
FUNCTION: Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.
SUBUNIT: Heterooligomer. Interacts with ZNT5 (By similarity).
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles.
TISSUE SPECIFICITY: Expressed in brain and liver, and to a lower extent also in lung. Highly expressed in brain (at protein level).
MISCELLANEOUS: Seems to have lost most of the histidine residues in the loop between the fourth and fifth transmembrane regions and appears to exert transport function by forming complexes with ZNT5.
SIMILARITY: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
SEQUENCE CAUTION: Sequence=AAH05753.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.2058-0.348 Picture PostScript Text
3' UTR -164.00707-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002524 - Cation_efflux

Pfam Domains:
PF01545 - Cation efflux family

SCOP Domains:
161111 - Cation efflux protein transmembrane domain-like

ModBase Predicted Comparative 3D Structure on Q8BJM5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
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Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005385 zinc ion transmembrane transporter activity
GO:0008324 cation transmembrane transporter activity

Biological Process:
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006829 zinc II ion transport
GO:0006895 Golgi to endosome transport
GO:0010043 response to zinc ion
GO:0055085 transmembrane transport
GO:0061088 regulation of sequestering of zinc ion
GO:0071577 zinc II ion transmembrane transport
GO:0098655 cation transmembrane transport

Cellular Component:
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC068169 - Mus musculus solute carrier family 30 (zinc transporter), member 6, mRNA (cDNA clone MGC:92967 IMAGE:30542277), complete cds.
AK160903 - Mus musculus 18 days pregnant adult female placenta and extra embryonic tissue cDNA, RIKEN full-length enriched library, clone:3830404B04 product:solute carrier family 30 (zinc transporter), member 6, full insert sequence.
AK082907 - Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430015M18 product:solute carrier family 30 (zinc transporter), member 6, full insert sequence.
AK150342 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830003M22 product:solute carrier family 30 (zinc transporter), member 6, full insert sequence.
AK151120 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830025I04 product:solute carrier family 30 (zinc transporter), member 6, full insert sequence.
AK020581 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530029F08 product:unclassifiable, full insert sequence.
BC066162 - Mus musculus solute carrier family 30 (zinc transporter), member 6, mRNA (cDNA clone MGC:76525 IMAGE:30471027), complete cds.
AF395840 - Mus musculus zinc transporter 6 (Znt6) mRNA, complete cds.
AF233346 - Mus musculus zinc transporter-like 3 protein mRNA, complete cds.
AK041450 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630010P05 product:unclassifiable, full insert sequence.
BC005753 - Mus musculus solute carrier family 30 (zinc transporter), member 6, mRNA (cDNA clone IMAGE:3600882), complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8BJM5 (Reactome details) participates in the following event(s):

R-MMU-437139 ZnT6 transports zinc into the golgi apparatus
R-MMU-264876 Insulin processing
R-MMU-435368 Zinc efflux and compartmentalization by the SLC30 family
R-MMU-2980736 Peptide hormone metabolism
R-MMU-435354 Zinc transporters
R-MMU-392499 Metabolism of proteins
R-MMU-425410 Metal ion SLC transporters
R-MMU-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-MMU-425407 SLC-mediated transmembrane transport
R-MMU-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: NM_144798, Q3UB35, Q6NVE0, Q8BJM5, Q8K4H6, Q8R4Z2, Q99JQ3, uc008dob.1, uc008dob.2, uc008dob.3, Znt6, ZNT6_MOUSE
UCSC ID: uc008dob.3
RefSeq Accession: NM_144798
Protein: Q8BJM5 (aka ZNT6_MOUSE)
CCDS: CCDS37691.1, CCDS57109.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.