ID:ZNT6_MOUSE DESCRIPTION: RecName: Full=Zinc transporter 6; Short=ZnT-6; AltName: Full=Solute carrier family 30 member 6; FUNCTION: Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. SUBUNIT: Heterooligomer. Interacts with ZNT5 (By similarity). SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles. TISSUE SPECIFICITY: Expressed in brain and liver, and to a lower extent also in lung. Highly expressed in brain (at protein level). MISCELLANEOUS: Seems to have lost most of the histidine residues in the loop between the fourth and fifth transmembrane regions and appears to exert transport function by forming complexes with ZNT5. SIMILARITY: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. SEQUENCE CAUTION: Sequence=AAH05753.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 161111 - Cation efflux protein transmembrane domain-like
ModBase Predicted Comparative 3D Structure on Q8BJM5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC068169 - Mus musculus solute carrier family 30 (zinc transporter), member 6, mRNA (cDNA clone MGC:92967 IMAGE:30542277), complete cds. AK160903 - Mus musculus 18 days pregnant adult female placenta and extra embryonic tissue cDNA, RIKEN full-length enriched library, clone:3830404B04 product:solute carrier family 30 (zinc transporter), member 6, full insert sequence. AK082907 - Mus musculus 7 days embryo whole body cDNA, RIKEN full-length enriched library, clone:C430015M18 product:solute carrier family 30 (zinc transporter), member 6, full insert sequence. AK150342 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830003M22 product:solute carrier family 30 (zinc transporter), member 6, full insert sequence. AK151120 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830025I04 product:solute carrier family 30 (zinc transporter), member 6, full insert sequence. AK020581 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530029F08 product:unclassifiable, full insert sequence. BC066162 - Mus musculus solute carrier family 30 (zinc transporter), member 6, mRNA (cDNA clone MGC:76525 IMAGE:30471027), complete cds. AF395840 - Mus musculus zinc transporter 6 (Znt6) mRNA, complete cds. AF233346 - Mus musculus zinc transporter-like 3 protein mRNA, complete cds. AK041450 - Mus musculus 3 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A630010P05 product:unclassifiable, full insert sequence. BC005753 - Mus musculus solute carrier family 30 (zinc transporter), member 6, mRNA (cDNA clone IMAGE:3600882), complete cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8BJM5 (Reactome details) participates in the following event(s):
R-MMU-437139 ZnT6 transports zinc into the golgi apparatus R-MMU-264876 Insulin processing R-MMU-435368 Zinc efflux and compartmentalization by the SLC30 family R-MMU-2980736 Peptide hormone metabolism R-MMU-435354 Zinc transporters R-MMU-392499 Metabolism of proteins R-MMU-425410 Metal ion SLC transporters R-MMU-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-MMU-425407 SLC-mediated transmembrane transport R-MMU-382551 Transport of small molecules