ID:ABCG8_MOUSE DESCRIPTION: RecName: Full=ATP-binding cassette sub-family G member 8; AltName: Full=Sterolin-2; FUNCTION: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. SUBUNIT: May form heterodimers with ABCG5 or be tightly coupled to ABCG5 along a pathway regulating diatery-sterol absorption and excretion (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable). TISSUE SPECIFICITY: Expressed in the intestine and, at lower level, in the liver. INDUCTION: Up-regulated by cholesterol feeding. Possibly mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Endotoxin (LPS) significantly decreased mRNA levels in the liver but not in the small intestine. SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. SIMILARITY: Contains 1 ABC transmembrane type-2 domain. SIMILARITY: Contains 1 ABC transporter domain. CAUTION: Seems to have a defective ATP-binding region.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9DBM0
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0005524 ATP binding GO:0015248 sterol transporter activity GO:0016887 ATPase activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity GO:0017127 cholesterol transporter activity
AK050938 - Mus musculus 9 days embryo whole body cDNA, RIKEN full-length enriched library, clone:D030040P06 product:ATP-BINDING CASSETTE, SUB-FAMILY G, MEMBER 8 (STEROLIN-2) homolog [Mus musculus], full insert sequence. AY196215 - Mus musculus strain I/LnJ ATP-binding cassette sub-family G member 8 (Abcg8) mRNA, complete cds. AY196216 - Mus musculus strain PERA/Ei ATP-binding cassette sub-family G member 8 (Abcg8) mRNA, complete cds. AF324495 - Mus musculus sterolin-2 (Abcg8) mRNA, complete cds. BC138484 - Mus musculus ATP-binding cassette, sub-family G (WHITE), member 8, mRNA (cDNA clone MGC:170109 IMAGE:8861504), complete cds. BC145293 - Mus musculus ATP-binding cassette, sub-family G (WHITE), member 8, mRNA (cDNA clone MGC:178855 IMAGE:9053847), complete cds. AK004871 - Mus musculus adult male liver cDNA, RIKEN full-length enriched library, clone:1300003C16 product:ATP-binding cassette, sub-family G (WHITE), member 8, full insert sequence. AK008188 - Mus musculus adult male small intestine cDNA, RIKEN full-length enriched library, clone:2010011G12 product:ATP-binding cassette, sub-family G (WHITE), member 8, full insert sequence.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu02010 - ABC transporters mmu04975 - Fat digestion and absorption mmu04976 - Bile secretion
Reactome (by CSHL, EBI, and GO)
Protein Q9DBM0 (Reactome details) participates in the following event(s):
R-MMU-265783 ABCG5:ABCG8 transports sterols from cytosol to extracellular region R-MMU-1369062 ABC transporters in lipid homeostasis R-MMU-382556 ABC-family proteins mediated transport R-MMU-382551 Transport of small molecules
US Server
