Mouse Gene Zfp24 (ENSMUST00000153337.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically bind to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro. (from UniProt Q91VN1) Gencode Transcript: ENSMUST00000153337.1 Gencode Gene: ENSMUSG00000051469.14 Transcript (Including UTRs) Position: mm10 chr18:24,013,925-24,020,320 Size: 6,396 Total Exon Count: 4 Strand: - Coding Region Position: mm10 chr18:24,014,147-24,018,087 Size: 3,941 Coding Exon Count: 3
ID:ZNF24_MOUSE DESCRIPTION: RecName: Full=Zinc finger protein 24; AltName: Full=Hypomyelinated CNS protein; AltName: Full=Zinc finger protein 191; Short=Zfp-191; AltName: Full=Zinc finger protein ZF-12; FUNCTION: Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically bind to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed with highest levels in heart, brain, liver, skeletal muscle, kidney and testis and very low levels in spleen and lung. DEVELOPMENTAL STAGE: In the embryo, barely detectable at day 17, peaks at day 11 and remains constant thereafter. Detected early during embryogenesis in ectodermal, endodermal, mesodermal and extraembryonic tissues. Expressed in the developing central nervous system. In the developing central nervous system (CNS), mainly expressed in progenitors. PTM: Sumoylated (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). DISRUPTION PHENOTYPE: According to PubMed:20080941, most mice die by postnatal day 25 (P25) due to myelination defects. Brains and spinal cords isolated from P14 mice appear to be smaller than those from wild-type mice and to lack white matter. Mutant oligodendrocytes arrest at a late stage of differentiation. Expression of genes expressed specifically in mature myelinating oligodendrocytes is down-regulated. According to PubMed:17064688, embryos are severely retarded in development and die at approximately 7.5 days post-fertilization (E7.5). One possible explanation for the different phenotypes described is that the two null alleles are not identical. In the mutants described by PubMed:20080941, the PGK-neo cassette used for positive selection of embryonic stem (ES) cells has been removed, whereas it remains in the allele described by PubMed:17064688. SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family. SIMILARITY: Contains 4 C2H2-type zinc fingers. SIMILARITY: Contains 1 SCAN box domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q91VN1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0042552 myelination GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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