Mouse Gene Mrpl49 (ENSMUST00000007482.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus mitochondrial ribosomal protein L49 (Mrpl49), mRNA. (from RefSeq NM_026246)
Gencode Transcript: ENSMUST00000007482.7
Gencode Gene: ENSMUSG00000007338.10
Transcript (Including UTRs)
   Position: mm10 chr19:6,053,622-6,057,785 Size: 4,164 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chr19:6,054,836-6,057,736 Size: 2,901 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:6,053,622-6,057,785)mRNA (may differ from genome)Protein (166 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: RM49_MOUSE
DESCRIPTION: RecName: Full=39S ribosomal protein L49, mitochondrial; Short=L49mt; Short=MRP-L49;
SUBUNIT: Interacts with OXA1L (By similarity).
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the ribosomal protein L49em family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.2049-0.331 Picture PostScript Text
3' UTR -374.001214-0.308 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007740 - Ribosomal_L49/IMG2

Pfam Domains:
PF05046 - Mitochondrial large subunit ribosomal protein (Img2)

SCOP Domains:
55159 - eIF1-like

ModBase Predicted Comparative 3D Structure on Q9CQ40
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
     Gene Details
     Gene Sorter
 RGDEnsemblEnsemblWormBaseSGD
 Protein Sequence Protein SequenceProtein Sequence 
 Alignment AlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003735 structural constituent of ribosome

Biological Process:
GO:0006412 translation
GO:0008150 biological_process

Cellular Component:
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome


-  Descriptions from all associated GenBank mRNAs
  LF201591 - JP 2014500723-A/9094: Polycomb-Associated Non-Coding RNAs.
LF205076 - JP 2014500723-A/12579: Polycomb-Associated Non-Coding RNAs.
AK150572 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830012D15 product:mitochondrial ribosomal protein L49, full insert sequence.
AK150715 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830013P06 product:mitochondrial ribosomal protein L49, full insert sequence.
AK014723 - Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4833419D18 product:mitochondrial ribosomal protein L49, full insert sequence.
AK180468 - Mus musculus cDNA, clone:Y0G0114G13, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000056166, based on BLAT search.
BC028956 - Mus musculus mitochondrial ribosomal protein L49, mRNA (cDNA clone MGC:35661 IMAGE:5368499), complete cds.
AK049794 - Mus musculus 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530050F05 product:mitochondrial ribosomal protein L49, full insert sequence.
AK077397 - Mus musculus 6 days neonate head cDNA, RIKEN full-length enriched library, clone:5430428O05 product:mitochondrial ribosomal protein L49, full insert sequence.
AK011273 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610002C10 product:mitochondrial ribosomal protein L49, full insert sequence.
LF256541 - JP 2014500723-A/64044: Polycomb-Associated Non-Coding RNAs.
LF256542 - JP 2014500723-A/64045: Polycomb-Associated Non-Coding RNAs.
LF256543 - JP 2014500723-A/64046: Polycomb-Associated Non-Coding RNAs.
AK027949 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110031O23 product:mitochondrial ribosomal protein L49, full insert sequence.
AK007712 - Mus musculus 10 day old male pancreas cDNA, RIKEN full-length enriched library, clone:1810037A06 product:mitochondrial ribosomal protein L49, full insert sequence.
AK003040 - Mus musculus adult male brain cDNA, RIKEN full-length enriched library, clone:0710008G23 product:mitochondrial ribosomal protein L49, full insert sequence.
AK217865 - Mus musculus cDNA, clone:Y2G0143E14, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007482, based on BLAT search.
AK210880 - Mus musculus cDNA, clone:Y2G0119P06, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000007482, based on BLAT search.
MA437168 - JP 2018138019-A/9094: Polycomb-Associated Non-Coding RNAs.
MA440653 - JP 2018138019-A/12579: Polycomb-Associated Non-Coding RNAs.
MA492118 - JP 2018138019-A/64044: Polycomb-Associated Non-Coding RNAs.
MA492119 - JP 2018138019-A/64045: Polycomb-Associated Non-Coding RNAs.
MA492120 - JP 2018138019-A/64046: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9CQ40 (Reactome details) participates in the following event(s):

R-MMU-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits
R-MMU-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP
R-MMU-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
R-MMU-5419281 MRRF binds 55S ribosome:mRNA:tRNA
R-MMU-5419276 Mitochondrial translation termination
R-MMU-5368287 Mitochondrial translation
R-MMU-5389840 Mitochondrial translation elongation
R-MMU-72766 Translation
R-MMU-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: NM_026246, Q3UC21, Q8C5R0, Q8C7P3, Q9CQ40, RM49_MOUSE, uc008ggq.1, uc008ggq.2
UCSC ID: uc008ggq.2
RefSeq Accession: NM_026246
Protein: Q9CQ40 (aka RM49_MOUSE)
CCDS: CCDS29488.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.