ID:S22A8_MOUSE DESCRIPTION: RecName: Full=Solute carrier family 22 member 8; AltName: Full=Organic anion transporter 3; Short=mOat3; AltName: Full=Reduced in osteosclerosis transporter; FUNCTION: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Mediates the uptake of p-amino-hippurate (PAH) and estron sulfate (ES). Also mediates uptake of several organic compounds such as prostaglandin E(2), prostaglandin F(2-alpha), allopurinol, 6-mercaptopurine (6-MP), 5-fluorouracil (5-FU), and L-carnitine. SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein (Potential). Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). TISSUE SPECIFICITY: Highly expressed in kidney. Expressed in developing bone. Weakly expressed in brain and eye. DISRUPTION PHENOTYPE: Mice appear healthly and are fertile. Exhibit a loss of taurocholate, estrone sulfate and para- aminohippurate transport in kidney and of fluorescein (FL) transport in choroid plexus. SIMILARITY: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on O88909
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0009636 response to toxic substance GO:0015697 quaternary ammonium group transport GO:0015698 inorganic anion transport GO:0034635 glutathione transport GO:0043252 sodium-independent organic anion transport GO:0055085 transmembrane transport
AK031962 - Mus musculus adult male medulla oblongata cDNA, RIKEN full-length enriched library, clone:6330513A04 product:reduced in osteosclerosis transporter, full insert sequence. AK157891 - Mus musculus adult inner ear cDNA, RIKEN full-length enriched library, clone:F930004N22 product:solute carrier family 22 (organic anion transporter), member 8, full insert sequence. BC014762 - Mus musculus solute carrier family 22 (organic anion transporter), member 8, mRNA (cDNA clone MGC:25962 IMAGE:4239544), complete cds. AK044336 - Mus musculus adult retina cDNA, RIKEN full-length enriched library, clone:A930007P06 product:reduced in osteosclerosis transporter, full insert sequence. AF078869 - Mus musculus reduced in osteosclerosis transporter (Roct) mRNA, complete cds. AB079895 - Mus musculus mRNA for organic anion transporter 3, partial cds.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04976 - Bile secretion
Reactome (by CSHL, EBI, and GO)
Protein O88909 (Reactome details) participates in the following event(s):
R-MMU-561041 OAT1-3 transport organic anions with antiport of dicarboxylic acids R-MMU-561048 Organic anion transport R-MMU-549132 Organic cation/anion/zwitterion transport R-MMU-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-MMU-425407 SLC-mediated transmembrane transport R-MMU-382551 Transport of small molecules
US Server
