Mouse Gene A1cf (ENSMUST00000224564.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity). (from UniProt Q5YD48) Gencode Transcript: ENSMUST00000224564.1 Gencode Gene: ENSMUSG00000052595.8 Transcript (Including UTRs) Position: mm10 chr19:31,868,764-31,932,848 Size: 64,085 Total Exon Count: 8 Strand: + Coding Region Position: mm10 chr19:31,893,100-31,932,712 Size: 39,613 Coding Exon Count: 7
ID:A1CF_MOUSE DESCRIPTION: RecName: Full=APOBEC1 complementation factor; AltName: Full=APOBEC1-stimulating protein; FUNCTION: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity). SUBUNIT: Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Endoplasmic reticulum (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum. Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1 (By similarity). TISSUE SPECIFICITY: Expressed primarily in liver, small intestine and kidney. DOMAIN: The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C- terminal regions are required for RNA-binding and for complementing APOBEC1 activity (By similarity). DISRUPTION PHENOTYPE: Mice display embryonic lethality at E3.5 due to failure of embryos to implant. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5YD48
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
