ID:SLIT1_MOUSE DESCRIPTION: RecName: Full=Slit homolog 1 protein; Short=Slit-1; Flags: Precursor; FUNCTION: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. SUBUNIT: Interacts with GREM1 (By similarity) and ROBO1. SUBCELLULAR LOCATION: Secreted (By similarity). DEVELOPMENTAL STAGE: During retinal development, is expressed at E12.5 in the dorsocentral region of the retina, and at E17.5 is only very weakly expressed. In the developing optic chiasm is expressed at E12.5 around the junction of the optic nerve and the brain, with strongest expression dorsal to the site at which the optic stalk joins the diencephalon, and also weakly in a subset of the CD44/SSEA neurons. In the more dorsal region of the developing optic chiasm, is expressed in some distance posterior to the axons. However, more ventrally, is expressed in a region directly adjacent to the path taken by the RGC axons. By E17.5 is not longer be detected at the junction of the brain and optic nerve and is only weakly expressed by the CD44/SSEA neurons. Outside the developing brain detected at between E8.5 and E9.5 in the primordiun of the branchial arches, between E9.5 and 10.5 in the posterior dermamyotome. By E11.5 the expression pattern along somite boundaries was most prominent caudally. Weak expression was also observed in the nasal pit at E11.5. From E13.5 to E17.5 expression was observed in the trigeminal ganglion, in the olfactory epithelium, and in the neural layer of the retina in the developing eye (with strongest expression in the inner nuclear layer). DISRUPTION PHENOTYPE: Mice show significant axon guidance errors in a variety of pathways, including corticofugal, callosal and thalamocortical tracts. Mice double-deficient in SLIT1 and SLIT2 show retinal axon guidance defects and a disorganized lateral olfactory tract (LOT). SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. SIMILARITY: Contains 9 EGF-like domains. SIMILARITY: Contains 1 laminin G-like domain. SIMILARITY: Contains 20 LRR (leucine-rich) repeats. SIMILARITY: Contains 4 LRRCT domains. SIMILARITY: Contains 4 LRRNT domains. SEQUENCE CAUTION: Sequence=BAC65658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q80TR4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.