Mouse Gene Trdmt1 (ENSMUST00000124488.6) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus tRNA aspartic acid methyltransferase 1 (Trdmt1), mRNA. (from RefSeq NM_010067)
Gencode Transcript: ENSMUST00000124488.6
Gencode Gene: ENSMUSG00000026723.10
Transcript (Including UTRs)
   Position: mm10 chr2:13,509,014-13,544,668 Size: 35,655 Total Exon Count: 11 Strand: -
Coding Region
   Position: mm10 chr2:13,511,518-13,544,632 Size: 33,115 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:13,509,014-13,544,668)mRNA (may differ from genome)Protein (415 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q5I0V6_MOUSE
DESCRIPTION: SubName: Full=DNA methyltransferase 2; SubName: Full=tRNA aspartic acid methyltransferase 1;
SIMILARITY: Belongs to the C5-methyltransferase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.1036-0.308 Picture PostScript Text
3' UTR -639.602504-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018117 - C5_DNA_meth_AS
IPR001525 - C5_MeTfrase
IPR025813 - tRNA_MeTrfase_TRDMT1

Pfam Domains:
PF00145 - C-5 cytosine-specific DNA methylase

SCOP Domains:
53335 - S-adenosyl-L-methionine-dependent methyltransferases

ModBase Predicted Comparative 3D Structure on Q5I0V6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0001975 response to amphetamine
GO:0030488 tRNA methylation
GO:0032259 methylation

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK029136 - Mus musculus 10 days neonate skin cDNA, RIKEN full-length enriched library, clone:4732496H19 product:DNA methyltransferase 2, full insert sequence.
AK050403 - Mus musculus adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730045C11 product:DNA methyltransferase 2, full insert sequence.
AF012129 - Mus musculus putative DNA methyltransferase (Dnmt2) mRNA, complete cds.
BC087892 - Mus musculus tRNA aspartic acid methyltransferase 1, mRNA (cDNA clone MGC:107176 IMAGE:30504522), complete cds.
AF045889 - Mus musculus putative DNA cytosine methyltransferase DNMT2 (Dnmt2) mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00270 - Cysteine and methionine metabolism
mmu01100 - Metabolic pathways

-  Other Names for This Gene
  Alternate Gene Symbols: Dnmt2, mCG_15707, NM_010067, Q5I0V6, Q5I0V6_MOUSE, RP23-14I24.1-001, uc008ika.1, uc008ika.2, uc008ika.3
UCSC ID: uc008ika.3
RefSeq Accession: NM_010067
Protein: Q5I0V6 CCDS: CCDS15695.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.