ID:TBB4B_MOUSE DESCRIPTION: RecName: Full=Tubulin beta-4B chain; AltName: Full=Tubulin beta-2C chain; FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. SUBUNIT: Dimer of alpha and beta chains. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. DOMAIN: The highly acidic C-terminal region may bind cations such as calcium. PTM: Some glutamate residues at the C-terminus are either polyglutamylated or polyglycylated. These 2 modifications occur exclusively on glutamate residues and result in either polyglutamate or polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they are regulate the assembly and dynamics of axonemal microtubules. SIMILARITY: Belongs to the tubulin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P68372
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04145 - Phagosome mmu04540 - Gap junction
Reactome (by CSHL, EBI, and GO)
Protein P68372 (Reactome details) participates in the following event(s):
R-MMU-380272 Plk1-mediated phosphorylation of Nlp R-MMU-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-MMU-380294 Loss of C-Nap-1 from centrosomes R-MMU-380311 Recruitment of Plk1 to centrosomes R-MMU-380303 Dissociation of Phospho-Nlp from the centrosome R-MMU-5626220 C2CD3 binds the mother centriole R-MMU-6798751 Exocytosis of azurophil granule lumen proteins R-MMU-380508 Translocation of NuMA to the centrosomes R-MMU-2574845 AJUBA binds centrosome-associated AURKA R-MMU-8853405 TPX2 binds AURKA at centrosomes R-MMU-3000319 BORA binds PLK1 and AURKA R-MMU-2574840 AJUBA facilitates AURKA autophosphorylation R-MMU-3000310 AURKA phosphorylates PLK1 R-MMU-5626681 Recruitment of transition zone proteins R-MMU-5626227 CP110 and CEP97 dissociate from the centriole R-MMU-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-MMU-380316 Association of NuMA with microtubules R-MMU-8853419 TPX2 promotes AURKA autophosphorylation R-MMU-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-MMU-5626228 The distal appendage proteins recruit TTBK2 R-MMU-5626699 MARK4 binds ODF2 in the centriole R-MMU-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-MMU-380259 Loss of Nlp from mitotic centrosomes R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes R-MMU-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-MMU-5620912 Anchoring of the basal body to the plasma membrane R-MMU-6798695 Neutrophil degranulation R-MMU-380320 Recruitment of NuMA to mitotic centrosomes R-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition R-MMU-8854518 AURKA Activation by TPX2 R-MMU-380287 Centrosome maturation R-MMU-5617833 Cilium Assembly R-MMU-168249 Innate Immune System R-MMU-68877 Mitotic Prometaphase R-MMU-69275 G2/M Transition R-MMU-1852241 Organelle biogenesis and maintenance R-MMU-168256 Immune System R-MMU-68886 M Phase R-MMU-453274 Mitotic G2-G2/M phases R-MMU-69278 Cell Cycle (Mitotic) R-MMU-1640170 Cell Cycle
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