ID:STOM_MOUSE DESCRIPTION: RecName: Full=Erythrocyte band 7 integral membrane protein; AltName: Full=Protein 7.2b; AltName: Full=Stomatin; FUNCTION: Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating. SUBUNIT: Homooligomer containing between 9 and 12 monomers. Interacts with LANCL1 (By similarity). Interacts with ASIC1, ASIC2 and ASIC3. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome (By similarity). Note=Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts. Concentrates preferentially in plasma membrane protrusions and in a juxta- nuclear region which may represent Golgi-derived vesicles. Colocalizes with actin. TISSUE SPECIFICITY: Expressed in all sensory neurons of the dorsal root ganglia. In the CNS, expressed in many neurons of the spinal cord, medulla and pons. Expressed only in scattered neurons in the cortex, hippocampus, thalamus and basal ganglia. In the cerebellum, expressed in all Purkinje cells (at protein level). Widely expressed with high levels in heart, liver, skeletal muscle and testis and low levels in lung, brain and spleen. DEVELOPMENTAL STAGE: First expressed in the developing embryo at E11.5 when target innervation is complete. Expression continues into adulthood. SIMILARITY: Belongs to the band 7/mec-2 family. SEQUENCE CAUTION: Sequence=AAB18857.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P54116
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0070063 RNA polymerase binding
Biological Process: GO:0034765 regulation of ion transmembrane transport GO:0044829 positive regulation by host of viral genome replication GO:0048524 positive regulation of viral process GO:0051260 protein homooligomerization GO:0090314 positive regulation of protein targeting to membrane GO:1901585 regulation of acid-sensing ion channel activity
US Server
