Mouse Gene G6pc2 (ENSMUST00000005364.11) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus glucose-6-phosphatase, catalytic, 2 (G6pc2), transcript variant 1, mRNA. (from RefSeq NM_021331) RefSeq Summary (NM_021331): This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Gencode Transcript: ENSMUST00000005364.11 Gencode Gene: ENSMUSG00000005232.11 Transcript (Including UTRs) Position: mm10 chr2:69,219,971-69,227,841 Size: 7,871 Total Exon Count: 5 Strand: + Coding Region Position: mm10 chr2:69,220,033-69,227,079 Size: 7,047 Coding Exon Count: 5
ID:G6PC2_MOUSE DESCRIPTION: RecName: Full=Glucose-6-phosphatase 2; Short=G-6-Pase 2; Short=G6Pase 2; EC=3.1.3.9; AltName: Full=Islet-specific glucose-6-phosphatase catalytic subunit-related protein; FUNCTION: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). CATALYTIC ACTIVITY: D-glucose 6-phosphate + H(2)O = D-glucose + phosphate. PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). TISSUE SPECIFICITY: Specifically expressed in pancreatic islet cells, in particular those of beta-cell origin. Not detected in testis, kidney, muscle, liver, lung, spleen, brain, pituitary, gastric fundus or heart. DEVELOPMENTAL STAGE: Initial onset of expression in the pancreas is at E12 and prominent expression is detected at E14. INDUCTION: Up-regulated in islet cells cultured in hyperglycemic concentrations of glucose. PTM: N-glycosylated; the non-glycosylated form is more unstable and is degraded through the proteasome (By similarity). DISRUPTION PHENOTYPE: Mice are no overt anatomical or behavioral phenotype but display a mild metabolic phenotype. Upon fasting those mice exhibit a significant decrease in blood glucose and triacylglycerol compared to wild type mice. MISCELLANEOUS: G6pc2 is an autoantigen which is the natural target of a prevalent T-cell population causing insulin-dependent diabetes mellitus through destruction of pancreatic beta cells. SIMILARITY: Belongs to the glucose-6-phosphatase family. SEQUENCE CAUTION: Sequence=AAI11906.1; Type=Erroneous translation; Note=Wrong choice of CDS;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Z186
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.