ID:PDE11_MOUSE DESCRIPTION: RecName: Full=Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; EC=3.1.4.17; EC=3.1.4.35; AltName: Full=cAMP and cGMP phosphodiesterase 11A; FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively (By similarity). CATALYTIC ACTIVITY: Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate. CATALYTIC ACTIVITY: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate. COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity). ENZYME REGULATION: Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytosol (By similarity). TISSUE SPECIFICITY: Expressed in testis and developing spermatoza. DOMAIN: The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity (By similarity). DISRUPTION PHENOTYPE: Mice live well and have no impaired fertility. They do however display reduced sperm concentration, rate of forward progression and percentage of live spermatozoa. Pre-ejaculated sperm display increased premature/spontaneous capacitance. SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. SIMILARITY: Contains 2 GAF domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P0C1Q2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
