Mouse Gene Duox1 (ENSMUST00000099461.3) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus dual oxidase 1 (Duox1), mRNA. (from RefSeq NM_001099297)
Gencode Transcript: ENSMUST00000099461.3
Gencode Gene: ENSMUSG00000033268.8
Transcript (Including UTRs)
   Position: mm10 chr2:122,315,672-122,347,972 Size: 32,301 Total Exon Count: 33 Strand: +
Coding Region
   Position: mm10 chr2:122,315,703-122,347,392 Size: 31,690 Coding Exon Count: 33 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:122,315,672-122,347,972)mRNA (may differ from genome)Protein (1551 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: A2AQ92_MOUSE
DESCRIPTION: SubName: Full=Dual oxidase 1; SubName: Full=Protein Duox1;
SIMILARITY: Contains 1 FAD-binding FR-type domain.
SIMILARITY: Contains 1 ferric oxidoreductase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00310.000 Picture PostScript Text
3' UTR -175.40580-0.302 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd
IPR013112 - FAD-bd_8
IPR017927 - Fd_Rdtase_FAD-bd
IPR013130 - Fe3_Rdtase_TM_dom
IPR013121 - Fe_red_NAD-bd_6
IPR010255 - Haem_peroxidase
IPR002007 - Haem_peroxidase_animal
IPR019791 - Haem_peroxidase_animal_subgr
IPR017938 - Riboflavin_synthase-like_b-brl

Pfam Domains:
PF00036 - EF hand
PF01794 - Ferric reductase like transmembrane component
PF03098 - Animal haem peroxidase
PF08022 - FAD-binding domain
PF08030 - Ferric reductase NAD binding domain
PF13202 - EF hand
PF13405 - EF-hand domain
PF13833 - EF-hand domain pair

SCOP Domains:
47473 - EF-hand
48113 - Heme-dependent peroxidases
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
81665 - Calcium ATPase, transmembrane domain M

ModBase Predicted Comparative 3D Structure on A2AQ92
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016174 NAD(P)H oxidase activity
GO:0016491 oxidoreductase activity
GO:0020037 heme binding

Biological Process:
GO:0006979 response to oxidative stress
GO:0019221 cytokine-mediated signaling pathway
GO:0042335 cuticle development
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051591 response to cAMP
GO:0055114 oxidation-reduction process
GO:0072593 reactive oxygen species metabolic process
GO:0098869 cellular oxidant detoxification

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC166016 - Synthetic construct Mus musculus clone IMAGE:100066316, MGC:195453 dual oxidase 1 (Duox1) mRNA, encodes complete protein.
AK037033 - Mus musculus adult female vagina cDNA, RIKEN full-length enriched library, clone:9930101G15 product:DUAL OXIDASE homolog [Homo sapiens], full insert sequence.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein A2AQ92 (Reactome details) participates in the following event(s):

R-MMU-5693681 DUOX1,2 reduce O2 to H2O2
R-MMU-209968 Thyroxine biosynthesis
R-MMU-209776 Amine-derived hormones
R-MMU-71291 Metabolism of nitrogenous molecules
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A2AQ92, A2AQ92_MOUSE, NM_001099297, RP23-173H17.5-001, uc008map.1
UCSC ID: uc008map.1
RefSeq Accession: NM_001099297
Protein: A2AQ92 CCDS: CCDS38222.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.