ID:AP4E1_MOUSE DESCRIPTION: RecName: Full=AP-4 complex subunit epsilon-1; AltName: Full=AP-4 adapter complex subunit epsilon; AltName: Full=Adapter-related protein complex 4 subunit epsilon-1; AltName: Full=Epsilon subunit of AP-4; AltName: Full=Epsilon-adaptin; FUNCTION: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). SUBUNIT: Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1) (By similarity). SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network (By similarity). Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells (By similarity). SIMILARITY: Belongs to the adaptor complexes large subunit family. SEQUENCE CAUTION: Sequence=AK144636; Type=Frameshift; Positions=303;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q80V94
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
