ID:ITPA_MOUSE DESCRIPTION: RecName: Full=Inosine triphosphate pyrophosphatase; Short=ITPase; Short=Inosine triphosphatase; EC=3.6.1.19; AltName: Full=Non-canonical purine NTP pyrophosphatase; AltName: Full=Non-standard purine NTP pyrophosphatase; AltName: Full=Nucleoside-triphosphate diphosphatase; AltName: Full=Nucleoside-triphosphate pyrophosphatase; Short=NTPase; FUNCTION: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. CATALYTIC ACTIVITY: A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate. COFACTOR: Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese (By similarity). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=24.9 uM for dITP; KM=38.4 uM for dHAPTP; KM=667 uM for dGTP; Note=Vmax values are similar for dITP, dHAPTP and dGTP; SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). DISRUPTION PHENOTYPE: Accumulates ITP in erythrocytes. Accumulates inosine in RNA and deoxyinosine in DNA. SIMILARITY: Belongs to the HAM1 NTPase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9D892
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
