Mouse Gene Fkbp1a (ENSMUST00000044011.11) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus FK506 binding protein 1a (Fkbp1a), transcript variant 3, non-coding RNA. (from RefSeq NR_126058) RefSeq Summary (NM_008019): This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. Gencode Transcript: ENSMUST00000044011.11 Gencode Gene: ENSMUSG00000032966.14 Transcript (Including UTRs) Position: mm10 chr2:151,542,483-151,561,692 Size: 19,210 Total Exon Count: 5 Strand: + Coding Region Position: mm10 chr2:151,542,708-151,559,586 Size: 16,879 Coding Exon Count: 4
ID:FKB1A_MOUSE DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP1A; Short=PPIase FKBP1A; EC=5.2.1.8; AltName: Full=12 kDa FK506-binding protein; Short=12 kDa FKBP; Short=FKBP-12; AltName: Full=Calstabin-1; AltName: Full=FK506-binding protein 1A; Short=FKBP-1A; AltName: Full=Immunophilin FKBP12; AltName: Full=Rotamase; FUNCTION: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). ENZYME REGULATION: Inhibited by both FK506 and rapamycin. SUBUNIT: Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (By similarity). Interacts with ACVR1B and SMAD7. Interacts directly with RYR1, RYR2 and RYR3 (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the FKBP-type PPIase family. FKBP1 subfamily. SIMILARITY: Contains 1 PPIase FKBP-type domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P26883
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000413 protein peptidyl-prolyl isomerization GO:0001933 negative regulation of protein phosphorylation GO:0003007 heart morphogenesis GO:0006936 muscle contraction GO:0007183 SMAD protein complex assembly GO:0010039 response to iron ion GO:0019221 cytokine-mediated signaling pathway GO:0031000 response to caffeine GO:0031398 positive regulation of protein ubiquitination GO:0032092 positive regulation of protein binding GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0032880 regulation of protein localization GO:0032925 regulation of activin receptor signaling pathway GO:0042098 T cell proliferation GO:0050776 regulation of immune response GO:0051209 release of sequestered calcium ion into cytosol GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity GO:0060347 heart trabecula formation GO:0061077 chaperone-mediated protein folding GO:0097435 supramolecular fiber organization GO:1902991 regulation of amyloid precursor protein catabolic process GO:1990000 amyloid fibril formation
US Server
