Mouse Gene Slc2a10 (ENSMUST00000029196.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus solute carrier family 2 (facilitated glucose transporter), member 10 (Slc2a10), mRNA. (from RefSeq NM_130451)
RefSeq Summary (NM_130451): This gene encodes a class III facilitative glucose transporter. Mutations in the related gene in human are associated with arterial tortuosity syndrome. [provided by RefSeq, Dec 2013].
Gencode Transcript: ENSMUST00000029196.4
Gencode Gene: ENSMUSG00000027661.4
Transcript (Including UTRs)
   Position: mm10 chr2:165,503,787-165,519,917 Size: 16,131 Total Exon Count: 5 Strand: +
Coding Region
   Position: mm10 chr2:165,504,045-165,518,242 Size: 14,198 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:165,503,787-165,519,917)mRNA (may differ from genome)Protein (536 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: GTR10_MOUSE
DESCRIPTION: RecName: Full=Solute carrier family 2, facilitated glucose transporter member 10; AltName: Full=Glucose transporter type 10; Short=GLUT-10;
FUNCTION: Facilitative glucose transporter (By similarity).
SUBCELLULAR LOCATION: Endomembrane system; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity).
SIMILARITY: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -112.90258-0.438 Picture PostScript Text
3' UTR -556.001675-0.332 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
IPR005828 - Sub_transporter
IPR003663 - Sugar/inositol_transpt
IPR005829 - Sugar_transporter_CS

Pfam Domains:
PF00083 - Sugar (and other) transporter
PF07690 - Major Facilitator Superfamily

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q8VHD6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity
GO:0005351 sugar:proton symporter activity
GO:0005355 glucose transmembrane transporter activity
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0008643 carbohydrate transport
GO:0046323 glucose import
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
GO:1904659 glucose transmembrane transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK052156 - Mus musculus 13 days embryo heart cDNA, RIKEN full-length enriched library, clone:D330001H08 product:solute carrier family 2 (facilitated glucose transporter), member 10, full insert sequence.
BC137917 - Mus musculus solute carrier family 2 (facilitated glucose transporter), member 10, mRNA (cDNA clone MGC:169541 IMAGE:8860936), complete cds.
BC137920 - Mus musculus solute carrier family 2 (facilitated glucose transporter), member 10, mRNA (cDNA clone MGC:169544 IMAGE:8860939), complete cds.
AY029579 - Mus musculus glucose transporter 10 mRNA, complete cds.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8VHD6 (Reactome details) participates in the following event(s):

R-MMU-429094 SLC2A6,8,10,12 transport Glc from extracellular region to cytosol
R-MMU-189200 Cellular hexose transport
R-MMU-425407 SLC-mediated transmembrane transport
R-MMU-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: Glut10, GTR10_MOUSE, NM_130451, Q8VHD6, uc008nxv.1, uc008nxv.2, uc008nxv.3
UCSC ID: uc008nxv.3
RefSeq Accession: NM_130451
Protein: Q8VHD6 (aka GTR10_MOUSE)
CCDS: CCDS17083.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.