ID:PAR6B_MOUSE DESCRIPTION: RecName: Full=Partitioning defective 6 homolog beta; Short=PAR-6 beta; Short=PAR-6B; FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. SUBUNIT: Interacts with PARD3. Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. Part of a complex with PARD3, CDC42 or RAC1 and PRKCI or PRKCZ. Part of a complex with LLGL1 and PRKCI. Interacts with ALS2CR19. Interacts with ECT2 (By similarity). Interacts with MPP5. INTERACTION: P60953:CDC42 (xeno); NbExp=6; IntAct=EBI-81861, EBI-81752; Q8TEW0:PARD3 (xeno); NbExp=2; IntAct=EBI-81861, EBI-81968; SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Cell junction, tight junction. Note=Colocalizes with active form of CDC42 or RAC1 at membrane ruffles. Also localizes to tight junctions. TISSUE SPECIFICITY: Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. DOMAIN: The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. DOMAIN: The PDZ domain mediates the interaction with MPP5. SIMILARITY: Belongs to the PAR6 family. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 pseudo-CRIB domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9JK83
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
