Mouse Gene Adnp (ENSMUST00000088001.5) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus activity-dependent neuroprotective protein (Adnp), transcript variant 2, mRNA. (from RefSeq NM_009628) RefSeq Summary (NM_009628): This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]. Gencode Transcript: ENSMUST00000088001.5 Gencode Gene: ENSMUSG00000051149.15 Transcript (Including UTRs) Position: mm10 chr2:168,180,986-168,207,112 Size: 26,127 Total Exon Count: 4 Strand: - Coding Region Position: mm10 chr2:168,182,047-168,189,389 Size: 7,343 Coding Exon Count: 3
ID:ADNP_MOUSE DESCRIPTION: RecName: Full=Activity-dependent neuroprotector homeobox protein; AltName: Full=Activity-dependent neuroprotective protein; FUNCTION: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Expressed in the brain, with a higher expression in cerebellum and hippocampus. Weakly expressed in lung, kidney and intestine, and expressed at intermediate level in testis. INDUCTION: By the neuroprotective peptide VIP. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). MISCELLANEOUS: When isolated from the sequence, the neuroprotective peptide provides neuroprotection at subfemtomolar concentrations against toxicity associated with tetrodoxin (electrical blockade), the beta-amyloid peptide (the Alzheimer disease neurotoxin), N-methyl-aspartate (excitotoxicity), and the human immunideficiency virus (HIV) envelope protein. SIMILARITY: Contains 5 C2H2-type zinc fingers. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Z103
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007614 short-term memory GO:0009743 response to carbohydrate GO:0010035 response to inorganic substance GO:0010629 negative regulation of gene expression GO:0010835 regulation of protein ADP-ribosylation GO:0010976 positive regulation of neuron projection development GO:0030828 positive regulation of cGMP biosynthetic process GO:0031668 cellular response to extracellular stimulus GO:0032091 negative regulation of protein binding GO:0032147 activation of protein kinase activity GO:0033484 nitric oxide homeostasis GO:0043524 negative regulation of neuron apoptotic process GO:0044849 estrous cycle GO:0045773 positive regulation of axon extension GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050805 negative regulation of synaptic transmission GO:0051965 positive regulation of synapse assembly
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