Mouse Gene Postn (ENSMUST00000117373.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus periostin, osteoblast specific factor (Postn), transcript variant 5, mRNA. (from RefSeq NM_001313899) RefSeq Summary (NM_001198766): This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Gencode Transcript: ENSMUST00000117373.7 Gencode Gene: ENSMUSG00000027750.16 Transcript (Including UTRs) Position: mm10 chr3:54,361,109-54,391,034 Size: 29,926 Total Exon Count: 21 Strand: + Coding Region Position: mm10 chr3:54,361,143-54,390,299 Size: 29,157 Coding Exon Count: 21
ID:POSTN_MOUSE DESCRIPTION: RecName: Full=Periostin; Short=PN; AltName: Full=Osteoblast-specific factor 2; Short=OSF-2; Flags: Precursor; FUNCTION: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. TISSUE SPECIFICITY: Preferentially expressed in periosteum and periodontal ligament. Also expressed in the developing and adult heart. DEVELOPMENTAL STAGE: In the heart, expressed from embryonic day 10.5. Continues to be strongly expressed throughout cardiac development and into adulthood. INDUCTION: By TGF-beta. PTM: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. SIMILARITY: Contains 1 EMI domain. SIMILARITY: Contains 4 FAS1 domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q62009
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
