Mouse Gene Insrr (ENSMUST00000029711.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus insulin receptor-related receptor (Insrr), mRNA. (from RefSeq NM_011832)
Gencode Transcript: ENSMUST00000029711.8
Gencode Gene: ENSMUSG00000005640.11
Transcript (Including UTRs)
   Position: mm10 chr3:87,796,951-87,816,101 Size: 19,151 Total Exon Count: 22 Strand: +
Coding Region
   Position: mm10 chr3:87,797,424-87,815,375 Size: 17,952 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:87,796,951-87,816,101)mRNA (may differ from genome)Protein (1300 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: INSRR_MOUSE
DESCRIPTION: RecName: Full=Insulin receptor-related protein; Short=IRR; EC=2.7.10.1; AltName: Full=IR-related receptor; Contains: RecName: Full=Insulin receptor-related protein alpha chain; Contains: RecName: Full=Insulin receptor-related protein beta chain; Flags: Precursor;
FUNCTION: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBUNIT: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Highly expressed in the islets as well as in pancreatic beta-cells.
DOMAIN: The extracellular domain is required for sensing alterations in external pH (By similarity).
PTM: Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.
DISRUPTION PHENOTYPE: Renal function is impaired, with reduced ability of the collecting duct to adapt to alkalosis.
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
SIMILARITY: Contains 3 fibronectin type-III domains.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -175.30473-0.371 Picture PostScript Text
3' UTR -258.90726-0.357 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000494 - EGF_rcpt_L
IPR003961 - Fibronectin_type3
IPR006211 - Furin-like_Cys-rich_dom
IPR006212 - Furin_repeat
IPR009030 - Growth_fac_rcpt
IPR013783 - Ig-like_fold
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR008266 - Tyr_kinase_AS
IPR020635 - Tyr_kinase_cat_dom
IPR016246 - Tyr_kinase_insulin-like_rcpt
IPR002011 - Tyr_kinase_rcpt_2_CS

Pfam Domains:
PF00069 - Protein kinase domain
PF00757 - Furin-like cysteine rich region
PF01030 - Receptor L domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
49265 - Fibronectin type III
52058 - L domain-like
56112 - Protein kinase-like (PK-like)
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on Q9WTL4
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
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Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding

Biological Process:
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030238 male sex determination
GO:0031532 actin cytoskeleton reorganization
GO:0046777 protein autophosphorylation
GO:0071469 cellular response to alkaline pH

Cellular Component:
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex


-  Descriptions from all associated GenBank mRNAs
  AK142578 - Mus musculus 0 day neonate kidney cDNA, RIKEN full-length enriched library, clone:D630046L17 product:insulin receptor-related receptor, full insert sequence.
AK081512 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130025G13 product:insulin receptor-related receptor, full insert sequence.
AB007135 - Mus musculus IRR mRNA for insulin receptor-related receptor, complete cds.
BC137855 - Mus musculus insulin receptor-related receptor, mRNA (cDNA clone MGC:169479 IMAGE:8860874), complete cds.
AK136441 - Mus musculus adult male colon cDNA, RIKEN full-length enriched library, clone:9030216H21 product:insulin receptor-related receptor, full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04810 - Regulation of actin cytoskeleton
mmu05215 - Prostate cancer

-  Other Names for This Gene
  Alternate Gene Symbols: B2RQC5, INSRR_MOUSE, Irr, NM_011832, Q9WTL4, uc008psy.1, uc008psy.2
UCSC ID: uc008psy.2
RefSeq Accession: NM_011832
Protein: Q9WTL4 (aka INSRR_MOUSE or IRR_MOUSE)
CCDS: CCDS17454.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.