ID:INSRR_MOUSE DESCRIPTION: RecName: Full=Insulin receptor-related protein; Short=IRR; EC=2.7.10.1; AltName: Full=IR-related receptor; Contains: RecName: Full=Insulin receptor-related protein alpha chain; Contains: RecName: Full=Insulin receptor-related protein beta chain; Flags: Precursor; FUNCTION: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Highly expressed in the islets as well as in pancreatic beta-cells. DOMAIN: The extracellular domain is required for sensing alterations in external pH (By similarity). PTM: Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5. DISRUPTION PHENOTYPE: Renal function is impaired, with reduced ability of the collecting duct to adapt to alkalosis. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. SIMILARITY: Contains 3 fibronectin type-III domains. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF00757 - Furin-like cysteine rich region PF01030 - Receptor L domain PF07714 - Protein tyrosine kinase
SCOP Domains: 49265 - Fibronectin type III 52058 - L domain-like 56112 - Protein kinase-like (PK-like) 57184 - Growth factor receptor domain
ModBase Predicted Comparative 3D Structure on Q9WTL4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.