Mouse Gene Bglap (ENSMUST00000076048.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus bone gamma carboxyglutamate protein (Bglap), mRNA. (from RefSeq NM_007541) RefSeq Summary (NM_007541): This gene encodes one of the most abundant non-collagenous proteins in bone tissue that is localized to the mineralized matrix of bone. The encoded preproprotein undergoes proteolytic processing and post-translational gamma carboxylation to generate a mature, calcium-binding protein. Mice lacking the encoded protein develop abnormalities of bone remodelling. This gene is located adjacent to two other osteocalcin-related genes on chromosome 3. [provided by RefSeq, Oct 2015]. Gencode Transcript: ENSMUST00000076048.4 Gencode Gene: ENSMUSG00000074483.2 Transcript (Including UTRs) Position: mm10 chr3:88,383,501-88,384,433 Size: 933 Total Exon Count: 4 Strand: - Coding Region Position: mm10 chr3:88,383,635-88,384,415 Size: 781 Coding Exon Count: 4
ID:OSTCN_MOUSE DESCRIPTION: RecName: Full=Osteocalcin; AltName: Full=Bone Gla protein; Short=BGP; AltName: Full=Gamma-carboxyglutamic acid-containing protein; Flags: Precursor; FUNCTION: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Bone. PTM: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family. SIMILARITY: Contains 1 Gla (gamma-carboxy-glutamate) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P86546
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
U11542 - Mus musculus C57BL/6J ostecalcin precursor, bone gla protein mRNA, complete cds. BC165978 - Synthetic construct Mus musculus clone IMAGE:100066278, MGC:195415 bone gamma carboxyglutamate protein 1 (Bglap1) mRNA, encodes complete protein.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P86546 (Reactome details) participates in the following event(s):
R-MMU-6807214 GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) R-MMU-6807224 Furin cleaves pro-BGLAP to BGLAP R-MMU-159740 Gamma-carboxylation of protein precursors R-MMU-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus R-MMU-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins R-MMU-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins R-MMU-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation R-MMU-597592 Post-translational protein modification R-MMU-392499 Metabolism of proteins