Mouse Gene Efna4 (ENSMUST00000029674.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus ephrin A4 (Efna4), mRNA. (from RefSeq NM_007910)
Gencode Transcript: ENSMUST00000029674.7
Gencode Gene: ENSMUSG00000028040.7
Transcript (Including UTRs)
   Position: mm10 chr3:89,333,390-89,338,028 Size: 4,639 Total Exon Count: 4 Strand: -
Coding Region
   Position: mm10 chr3:89,334,290-89,337,950 Size: 3,661 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:89,333,390-89,338,028)mRNA (may differ from genome)Protein (206 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q3UQB5_MOUSE
DESCRIPTION: SubName: Full=Ephrin A4;
SIMILARITY: Belongs to the ephrin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.5078-0.340 Picture PostScript Text
3' UTR -318.30900-0.354 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008972 - Cupredoxin
IPR001799 - Ephrin
IPR019765 - Ephrin_CS

Pfam Domains:
PF00812 - Ephrin

SCOP Domains:
49503 - Cupredoxins

ModBase Predicted Comparative 3D Structure on Q3UQB5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046875 ephrin receptor binding

Biological Process:
GO:0048013 ephrin receptor signaling pathway

Cellular Component:
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK142604 - Mus musculus 10 days lactation, adult female mammary gland cDNA, RIKEN full-length enriched library, clone:D730009E04 product:ephrin A4, full insert sequence.
AK012195 - Mus musculus 10 days embryo whole body cDNA, RIKEN full-length enriched library, clone:2610529M21 product:ephrin A4, full insert sequence.
U90663 - Mus musculus ligand LERK-4 mRNA, complete cds.
BC160329 - Synthetic construct Mus musculus clone IMAGE:100064073, MGC:193444 ephrin A4 (Efna4) mRNA, encodes complete protein.
AK144085 - Mus musculus cDNA, RIKEN full-length enriched library, clone:G130205G22 product:ephrin A4, full insert sequence.
LF194004 - JP 2014500723-A/1507: Polycomb-Associated Non-Coding RNAs.
MA429581 - JP 2018138019-A/1507: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04360 - Axon guidance

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_17548, NM_007910, Q3UQB5, Q3UQB5_MOUSE, uc008pys.1, uc008pys.2
UCSC ID: uc008pys.2
RefSeq Accession: NM_007910
Protein: Q3UQB5 CCDS: CCDS38489.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.