ID:DSRAD_MOUSE DESCRIPTION: RecName: Full=Double-stranded RNA-specific adenosine deaminase; Short=DRADA; EC=3.5.4.-; AltName: Full=RNA adenosine deaminase 1; FUNCTION: Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses (By similarity). Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. SUBUNIT: Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus, nucleolus. Note=Long forms starting at Met-1 are found predominantly in cytoplasm. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus, nucleolus. Note=Long forms starting at Met-1 are found predominantly in cytoplasm. SUBCELLULAR LOCATION: Isoform 3: Nucleus, nucleolus. Note=Short forms starting at Met-519 are found exclusively in the nucleolus. SUBCELLULAR LOCATION: Isoform 4: Nucleus, nucleolus. Note=Short forms starting at Met-519 are found exclusively in the nucleolus. TISSUE SPECIFICITY: Highest levels in brain and spleen. Lowest levels in liver. INDUCTION: By inflammation. Under normal conditions, long forms starting at Met-1 are dominant. Inflammation causes selective induction of short forms starting at Met-519. PTM: Sumoylation reduces RNA-editing activity (By similarity). DISRUPTION PHENOTYPE: Mice do not survive past E11.0-E12.5 and embryos display widespread apoptosis, a rapidly disintegrating liver structure and severe defects in hematopoiesis. SIMILARITY: Contains 1 A to I editase domain. SIMILARITY: Contains 2 DRADA repeats. SIMILARITY: Contains 3 DRBM (double-stranded RNA-binding) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99MU3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001649 osteoblast differentiation GO:0001701 in utero embryonic development GO:0002244 hematopoietic progenitor cell differentiation GO:0002376 immune system process GO:0002566 somatic diversification of immune receptors via somatic mutation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006382 adenosine to inosine editing GO:0006396 RNA processing GO:0006397 mRNA processing GO:0006606 protein import into nucleus GO:0006611 protein export from nucleus GO:0009615 response to virus GO:0016553 base conversion or substitution editing GO:0030218 erythrocyte differentiation GO:0031047 gene silencing by RNA GO:0031054 pre-miRNA processing GO:0035196 production of miRNAs involved in gene silencing by miRNA GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA GO:0035455 response to interferon-alpha GO:0043066 negative regulation of apoptotic process GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0045070 positive regulation of viral genome replication GO:0045071 negative regulation of viral genome replication GO:0045087 innate immune response GO:0051607 defense response to virus GO:0060216 definitive hemopoiesis GO:0060339 negative regulation of type I interferon-mediated signaling pathway GO:0061484 hematopoietic stem cell homeostasis GO:0098586 cellular response to virus GO:1900369 negative regulation of RNA interference
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