Mouse Gene Gstm4 (ENSMUST00000029489.14) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus glutathione S-transferase, mu 4 (Gstm4), transcript variant 1, mRNA. (from RefSeq NM_026764)
Gencode Transcript: ENSMUST00000029489.14
Gencode Gene: ENSMUSG00000027890.17
Transcript (Including UTRs)
   Position: mm10 chr3:108,040,408-108,044,894 Size: 4,487 Total Exon Count: 8 Strand: -
Coding Region
   Position: mm10 chr3:108,041,236-108,044,672 Size: 3,437 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:108,040,408-108,044,894)mRNA (may differ from genome)Protein (218 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIPubMed
ReactomeSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q8R5I6_MOUSE
DESCRIPTION: SubName: Full=Glutathione S-transferase mu 4; SubName: Full=Glutathione S-transferase, mu 4; SubName: Full=Glutathione transferase GSTM7-7; EC=2.5.1.18; SubName: Full=Protein Gstm4;
SIMILARITY: Belongs to the GST superfamily.
SIMILARITY: Contains 1 GST C-terminal domain.
SIMILARITY: Contains 1 GST N-terminal domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -82.60222-0.372 Picture PostScript Text
3' UTR -297.20828-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010987 - Glutathione-S-Trfase_C-like
IPR004045 - Glutathione_S-Trfase_N
IPR017933 - Glutathione_S_Trfase/Cl_chnl_C
IPR004046 - GST_C
IPR003081 - GST_mu
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF00043 - Glutathione S-transferase, C-terminal domain
PF02798 - Glutathione S-transferase, N-terminal domain
PF14497 - Glutathione S-transferase, C-terminal domain

SCOP Domains:
47616 - GST C-terminal domain-like
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q8R5I6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0043295 glutathione binding

Biological Process:
GO:0006749 glutathione metabolic process
GO:0008152 metabolic process
GO:0018916 nitrobenzene metabolic process
GO:0042178 xenobiotic catabolic process

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0045171 intercellular bridge


-  Descriptions from all associated GenBank mRNAs
  AF464943 - Mus musculus glutathione transferase GSTM7-7 mRNA, complete cds.
BC030444 - Mus musculus glutathione S-transferase, mu 4, mRNA (cDNA clone MGC:40906 IMAGE:5373062), complete cds.
AF501320 - Mus musculus glutathione S-transferase mu 4 (Gstm4) mRNA, complete cds.
AK003418 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110004G14 product:GLUTATHIONE TRANSFERASE homolog [Homo sapiens], full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00480 - Glutathione metabolism
mmu00980 - Metabolism of xenobiotics by cytochrome P450
mmu00982 - Drug metabolism - cytochrome P450

BioCyc Knowledge Library
PWY-4061 - glutathione-mediated detoxification

Reactome (by CSHL, EBI, and GO)

Protein Q8R5I6 (Reactome details) participates in the following event(s):

R-MMU-9026777 GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1
R-MMU-176054 GST dimers conjugate GSH with cytosolic substrates
R-MMU-9026762 Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
R-MMU-156590 Glutathione conjugation
R-MMU-9026395 Biosynthesis of DHA-derived sulfido conjugates
R-MMU-156580 Phase II - Conjugation of compounds
R-MMU-9018677 Biosynthesis of DHA-derived SPMs
R-MMU-211859 Biological oxidations
R-MMU-9018678 Biosynthesis of specialized proresolving mediators (SPMs)
R-MMU-1430728 Metabolism
R-MMU-8978868 Fatty acid metabolism
R-MMU-556833 Metabolism of lipids

-  Other Names for This Gene
  Alternate Gene Symbols: NM_026764, Q8R5I6, Q8R5I6_MOUSE, RP23-214E3.8-001, uc008qxy.1, uc008qxy.2, uc008qxy.3
UCSC ID: uc008qxy.3
RefSeq Accession: NM_026764
Protein: Q8R5I6 CCDS: CCDS17748.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.