Mouse Gene Egf (ENSMUST00000197079.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus epidermal growth factor (Egf), transcript variant 2, mRNA. (from RefSeq NM_001310737) RefSeq Summary (NM_001310737): This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]. Gencode Transcript: ENSMUST00000197079.4 Gencode Gene: ENSMUSG00000028017.7 Transcript (Including UTRs) Position: mm10 chr3:129,677,578-129,725,087 Size: 47,510 Total Exon Count: 19 Strand: - Coding Region Position: mm10 chr3:129,678,320-129,718,013 Size: 39,694 Coding Exon Count: 15
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu04010 - MAPK signaling pathway mmu04012 - ErbB signaling pathway mmu04060 - Cytokine-cytokine receptor interaction mmu04144 - Endocytosis mmu04510 - Focal adhesion mmu04540 - Gap junction mmu04810 - Regulation of actin cytoskeleton mmu05160 - Hepatitis C mmu05200 - Pathways in cancer mmu05212 - Pancreatic cancer mmu05213 - Endometrial cancer mmu05214 - Glioma mmu05215 - Prostate cancer mmu05218 - Melanoma mmu05219 - Bladder cancer mmu05223 - Non-small cell lung cancer
BioCarta from NCI Cancer Genome Anatomy Project m_ErbB3Pathway - Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling m_cblPathway - CBL mediated ligand-induced downregulation of EGF receptors m_mCalpainPathway - mCalpain and friends in Cell motility m_egfr_smrtePathway - Map Kinase Inactivation of SMRT Corepressor m_keratinocytePathway - Keratinocyte Differentiation m_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy m_eea1Pathway - The role of FYVE-finger proteins in vesicle transport m_egfPathway - EGF Signaling Pathway m_spryPathway - Sprouty regulation of tyrosine kinase signals