Mouse Gene Eif4e (ENSMUST00000029803.11) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus eukaryotic translation initiation factor 4E (Eif4e), transcript variant 1, mRNA. (from RefSeq NM_007917)
RefSeq Summary (NM_007917): This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gencode Transcript: ENSMUST00000029803.11
Gencode Gene: ENSMUSG00000028156.12
Transcript (Including UTRs)
   Position: mm10 chr3:138,526,179-138,559,696 Size: 33,518 Total Exon Count: 8 Strand: +
Coding Region
   Position: mm10 chr3:138,527,297-138,555,504 Size: 28,208 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:138,526,179-138,559,696)mRNA (may differ from genome)Protein (217 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: Q3TK95_MOUSE
DESCRIPTION: SubName: Full=Putative uncharacterized protein;
SIMILARITY: Belongs to the eukaryotic initiation factor 4E family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.70145-0.315 Picture PostScript Text
3' UTR -1217.004192-0.290 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023398 - TIF_eIF4e-like_dom
IPR001040 - TIF_eIF_4E
IPR019770 - TIF_eIF_4E_CS

Pfam Domains:
PF01652 - Eukaryotic initiation factor 4E

SCOP Domains:
55418 - eIF4e-like

ModBase Predicted Comparative 3D Structure on Q3TK95
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserNo ortholog
Gene Details    Gene Details
Gene Sorter    Gene Sorter
GenBank EnsemblEnsemblWormBaseSGD
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0019899 enzyme binding
GO:0031370 eukaryotic initiation factor 4G binding
GO:0070491 repressing transcription factor binding

Biological Process:
GO:0001662 behavioral fear response
GO:0006412 translation
GO:0006413 translational initiation
GO:0017148 negative regulation of translation
GO:0019827 stem cell population maintenance
GO:0030324 lung development
GO:0045665 negative regulation of neuron differentiation
GO:0071549 cellular response to dexamethasone stimulus

Cellular Component:
GO:0005737 cytoplasm
GO:0005845 mRNA cap binding complex
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0032991 macromolecular complex
GO:0033391 chromatoid body
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF194231 - JP 2014500723-A/1734: Polycomb-Associated Non-Coding RNAs.
AK167097 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0030N12 product:eukaryotic translation initiation factor 4E, full insert sequence.
M61731 - Mus musculus translation initiation factor 4E (eIF-4E) mRNA, complete cds.
AK082867 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:C330046F16 product:eukaryotic translation initiation factor 4E, full insert sequence.
AK146757 - Mus musculus 16 days embryo heart cDNA, RIKEN full-length enriched library, clone:I920050I21 product:eukaryotic translation initiation factor 4E, full insert sequence.
BC010759 - Mus musculus eukaryotic translation initiation factor 4E, mRNA (cDNA clone MGC:18497 IMAGE:4216609), complete cds.
BC085087 - Mus musculus eukaryotic translation initiation factor 4E, mRNA (cDNA clone MGC:103177 IMAGE:6438419), complete cds.
MA429808 - JP 2018138019-A/1734: Polycomb-Associated Non-Coding RNAs.
LF269872 - JP 2014500723-A/77375: Polycomb-Associated Non-Coding RNAs.
LF269879 - JP 2014500723-A/77382: Polycomb-Associated Non-Coding RNAs.
LF269880 - JP 2014500723-A/77383: Polycomb-Associated Non-Coding RNAs.
LF269881 - JP 2014500723-A/77384: Polycomb-Associated Non-Coding RNAs.
LF269882 - JP 2014500723-A/77385: Polycomb-Associated Non-Coding RNAs.
LF269883 - JP 2014500723-A/77386: Polycomb-Associated Non-Coding RNAs.
LF269884 - JP 2014500723-A/77387: Polycomb-Associated Non-Coding RNAs.
LF269885 - JP 2014500723-A/77388: Polycomb-Associated Non-Coding RNAs.
AK020497 - Mus musculus 12 days embryo embryonic body between diaphragm region and neck cDNA, RIKEN full-length enriched library, clone:9430079G20 product:unclassifiable, full insert sequence.
MA505449 - JP 2018138019-A/77375: Polycomb-Associated Non-Coding RNAs.
MA505456 - JP 2018138019-A/77382: Polycomb-Associated Non-Coding RNAs.
MA505457 - JP 2018138019-A/77383: Polycomb-Associated Non-Coding RNAs.
MA505458 - JP 2018138019-A/77384: Polycomb-Associated Non-Coding RNAs.
MA505459 - JP 2018138019-A/77385: Polycomb-Associated Non-Coding RNAs.
MA505460 - JP 2018138019-A/77386: Polycomb-Associated Non-Coding RNAs.
MA505461 - JP 2018138019-A/77387: Polycomb-Associated Non-Coding RNAs.
MA505462 - JP 2018138019-A/77388: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu03013 - RNA transport
mmu04150 - mTOR signaling pathway
mmu04910 - Insulin signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
m_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
m_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
m_iresPathway - Internal Ribosome entry pathway
m_mTORPathway - mTOR Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: NM_007917, Q3TK95, Q3TK95_MOUSE, uc008rnn.1, uc008rnn.2, uc008rnn.3
UCSC ID: uc008rnn.3
RefSeq Accession: NM_007917
Protein: Q3TK95 CCDS: CCDS38654.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.