Mouse Gene Eif4e (ENSMUST00000029803.11) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus eukaryotic translation initiation factor 4E (Eif4e), transcript variant 1, mRNA. (from RefSeq NM_007917) RefSeq Summary (NM_007917): This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Gencode Transcript: ENSMUST00000029803.11 Gencode Gene: ENSMUSG00000028156.12 Transcript (Including UTRs) Position: mm10 chr3:138,526,179-138,559,696 Size: 33,518 Total Exon Count: 8 Strand: + Coding Region Position: mm10 chr3:138,527,297-138,555,504 Size: 28,208 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q3TK95
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.