ID:DDAH1_MOUSE DESCRIPTION: RecName: Full=N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; Short=DDAH-1; Short=Dimethylarginine dimethylaminohydrolase 1; EC=3.5.3.18; AltName: Full=DDAHI; AltName: Full=Dimethylargininase-1; FUNCTION: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. CATALYTIC ACTIVITY: N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline. ENZYME REGULATION: Inhibited by zinc ions (By similarity). SUBUNIT: Monomer (By similarity). TISSUE SPECIFICITY: Detected in skeletal muscle, lung, heart and brain (at protein level). Detected in liver, kidney and lung. DISRUPTION PHENOTYPE: Death at embryonic stages. Heterozygous mice show no visible phenotype, but have higher than normal tissue and plasma levels of asymmetric dimethylarginine (ADMA). They have increased mean arterial blood pressure and systemic vascular resistance, and decreased cardiac output and heart rate, probably due to reduced levels of nitric oxide (NO). SIMILARITY: Belongs to the DDAH family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9CWS0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000052 citrulline metabolic process GO:0003073 regulation of systemic arterial blood pressure GO:0006525 arginine metabolic process GO:0006527 arginine catabolic process GO:0006809 nitric oxide biosynthetic process GO:0008285 negative regulation of cell proliferation GO:0017014 protein nitrosylation GO:0043116 negative regulation of vascular permeability GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045766 positive regulation of angiogenesis GO:1900038 negative regulation of cellular response to hypoxia
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