Mouse Gene Zzz3 (ENSMUST00000106100.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus zinc finger, ZZ domain containing 3 (Zzz3), transcript variant 2, mRNA. (from RefSeq NM_001080755)
Gencode Transcript: ENSMUST00000106100.8
Gencode Gene: ENSMUSG00000039068.16
Transcript (Including UTRs)
   Position: mm10 chr3:152,396,003-152,462,826 Size: 66,824 Total Exon Count: 14 Strand: +
Coding Region
   Position: mm10 chr3:152,427,307-152,458,398 Size: 31,092 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:152,396,003-152,462,826)mRNA (may differ from genome)Protein (910 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ZZZ3_MOUSE
DESCRIPTION: RecName: Full=ZZ-type zinc finger-containing protein 3;
FUNCTION: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).
SUBUNIT: Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).
SIMILARITY: Contains 1 HTH myb-type DNA-binding domain.
SIMILARITY: Contains 1 ZZ-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -152.00446-0.341 Picture PostScript Text
3' UTR -1332.904428-0.301 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009057 - Homeodomain-like
IPR017930 - Myb_dom
IPR001005 - SANT/Myb
IPR000433 - Znf_ZZ

Pfam Domains:
PF00249 - Myb-like DNA-binding domain
PF00569 - Zinc finger, ZZ type
PF13921 - Myb-like DNA-binding domain

SCOP Domains:
46689 - Homeodomain-like
57850 - RING/U-box

ModBase Predicted Comparative 3D Structure on Q6KAQ7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
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Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008150 biological_process

Cellular Component:
GO:0005634 nucleus
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  AK165882 - Mus musculus lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730013F04 product:zinc finger, ZZ domain containing 3, full insert sequence.
AK131150 - Mus musculus mRNA for mFLJ00191 protein.
BC060614 - Mus musculus cDNA clone IMAGE:6417119, containing frame-shift errors.
AK132612 - Mus musculus 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4833421L15 product:zinc finger, ZZ domain containing 3, full insert sequence.
BC148610 - Synthetic construct Mus musculus clone IMAGE:100015555, MGC:183353 zinc finger, ZZ domain containing 3 (Zzz3) mRNA, encodes complete protein.
BC153178 - Synthetic construct Mus musculus clone IMAGE:100016517, MGC:184548 zinc finger, ZZ domain containing 3 (Zzz3) mRNA, encodes complete protein.
AK034365 - Mus musculus adult male diencephalon cDNA, RIKEN full-length enriched library, clone:9330183O17 product:hypothetical protein, full insert sequence.
BC023159 - Mus musculus zinc finger, ZZ domain containing 3, mRNA (cDNA clone IMAGE:4948746), with apparent retained intron.
BC080726 - Mus musculus cDNA clone IMAGE:6333530.
AK032496 - Mus musculus adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430567E01 product:unclassifiable, full insert sequence.
AK136540 - Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130204E07 product:unclassifiable, full insert sequence.
DQ551653 - Mus musculus piRNA piR-19765, complete sequence.
AB352509 - Mus musculus non-coding RNA, oocyte_piRNA3325, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001080755, Q3TMK6, Q3V189, Q6KAQ7, uc008rtn.1, uc008rtn.2, ZZZ3_MOUSE
UCSC ID: uc008rtn.2
RefSeq Accession: NM_001080755
Protein: Q6KAQ7 (aka ZZZ3_MOUSE)
CCDS: CCDS38674.1, CCDS71338.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.