Mouse Gene Mos (ENSMUST00000105158.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus Moloney sarcoma oncogene (Mos), mRNA. (from RefSeq NM_020021)
Gencode Transcript: ENSMUST00000105158.1
Gencode Gene: ENSMUSG00000078365.5
Transcript (Including UTRs)
   Position: mm10 chr4:3,870,657-3,872,105 Size: 1,449 Total Exon Count: 1 Strand: -
Coding Region
   Position: mm10 chr4:3,870,783-3,871,814 Size: 1,032 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:3,870,657-3,872,105)mRNA (may differ from genome)Protein (343 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MOS_MOUSE
DESCRIPTION: RecName: Full=Proto-oncogene serine/threonine-protein kinase mos; EC=2.7.11.1; AltName: Full=Oocyte maturation factor mos; AltName: Full=Proto-oncogene c-Mos;
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
TISSUE SPECIFICITY: Expressed specifically in testis during spermatogenesis.
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.80291-0.267 Picture PostScript Text
3' UTR -28.30126-0.225 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on P00536
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004871 signal transducer activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0000187 activation of MAPK activity
GO:0000212 meiotic spindle organization
GO:0006325 chromatin organization
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0040020 regulation of meiotic nuclear division
GO:0046777 protein autophosphorylation
GO:0051296 establishment of meiotic spindle orientation
GO:1902103 negative regulation of metaphase/anaphase transition of meiotic cell cycle

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK133089 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4930571D16 product:Moloney sarcoma oncogene, full insert sequence.
BC137690 - Mus musculus Moloney sarcoma oncogene, mRNA (cDNA clone MGC:169314 IMAGE:8860709), complete cds.
BC145745 - Mus musculus Moloney sarcoma oncogene, mRNA (cDNA clone MGC:175632 IMAGE:40131048), complete cds.
AB345921 - Mus musculus non-coding RNA, oocyte_clustered_small_RNA11122, complete sequence.
AB345923 - Mus musculus non-coding RNA, oocyte_clustered_small_RNA11124, complete sequence.
AB345924 - Mus musculus non-coding RNA, oocyte_clustered_small_RNA11125, complete sequence.
AB345925 - Mus musculus non-coding RNA, oocyte_clustered_small_RNA11126, complete sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04010 - MAPK signaling pathway
mmu04114 - Oocyte meiosis
mmu04810 - Regulation of actin cytoskeleton
mmu04914 - Progesterone-mediated oocyte maturation

-  Other Names for This Gene
  Alternate Gene Symbols: E9PV67, MOS_MOUSE, NM_020021, P00536, uc008rwo.1, uc008rwo.2
UCSC ID: uc008rwo.2
RefSeq Accession: NM_020021
Protein: P00536 (aka MOS_MOUSE)
CCDS: CCDS38685.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.