Mouse Gene Galt (ENSMUST00000084695.10) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus galactose-1-phosphate uridyl transferase (Galt), transcript variant 1, mRNA. (from RefSeq NM_016658) RefSeq Summary (NM_016658): The protein encoded by this gene is the second enzyme in the Leloir pathway, the metabolic pathway for D-galactose catabolism. It catalyzes the conversion of galactose-1-phosphate and uridine diphosphate-glucose to glucose-1-phosphate and uridine diphosphate galactose. Deficiency of this enzyme causes the genetic metabolic disorder galactosemia. Mice lacking this protein accumulate high levels of galactose and galactose-1 phosphate but are viable and fertile. This protein is negatively regulated through signaling by the polypeptide hormone prolactin, specifically via the short isoform of the prolactin receptor and the transcription factor Forkhead box O3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. Gencode Transcript: ENSMUST00000084695.10 Gencode Gene: ENSMUSG00000036073.17 Transcript (Including UTRs) Position: mm10 chr4:41,755,228-41,758,695 Size: 3,468 Total Exon Count: 11 Strand: + Coding Region Position: mm10 chr4:41,755,628-41,758,583 Size: 2,956 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 54197 - HIT-like 118116 - DNA mismatch repair protein MutL
ModBase Predicted Comparative 3D Structure on A2AMS3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0008270 zinc ion binding GO:0016740 transferase activity GO:0016779 nucleotidyltransferase activity GO:0046872 metal ion binding
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006011 UDP-glucose metabolic process GO:0006012 galactose metabolic process GO:0006258 UDP-glucose catabolic process GO:0033499 galactose catabolic process via UDP-galactose
US Server
