ID:UN13B_MOUSE DESCRIPTION: RecName: Full=Protein unc-13 homolog B; AltName: Full=Munc13-2; Short=munc13; FUNCTION: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. SUBUNIT: Interacts with RIMS1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus. Cell junction, synapse (By similarity). Note=Localized to synapses (By similarity). Translocates to the Golgi in response to phorbol ester binding. DOMAIN: The C2 domains are not involved in calcium-dependent phospholipid binding (By similarity). SIMILARITY: Belongs to the unc-13 family. SIMILARITY: Contains 3 C2 domains. SIMILARITY: Contains 1 MHD1 (MUNC13 homology domain 1) domain. SIMILARITY: Contains 1 MHD2 (MUNC13 homology domain 2) domain. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Z1N9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.