ID:PAPP1_MOUSE DESCRIPTION: RecName: Full=Pappalysin-1; EC=3.4.24.79; AltName: Full=Insulin-like growth factor-dependent IGF-binding protein 4 protease; Short=IGF-dependent IGFBP-4 protease; Short=IGFBP-4ase; AltName: Full=Pregnancy-associated plasma protein A; Short=PAPP-A; Flags: Precursor; FUNCTION: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected. CATALYTIC ACTIVITY: Cleavage of the 135-Met-|-Lys-136 bond in insulin-like growth factor binding protein (IGFBP)-4, and the 143- Ser-|-Lys-144 bond in IGFBP-5. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 (By similarity). SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Detected in kidney, spleen, brain, ovary, breast, skin, prostate, uterus, and placenta. SIMILARITY: Belongs to the peptidase M43B family. SIMILARITY: Contains 5 Sushi (CCP/SCR) domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases 55486 - Metalloproteases ("zincins"), catalytic domain 57535 - Complement control module/SCR domain 57184 - Growth factor receptor domain
ModBase Predicted Comparative 3D Structure on Q8R4K8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
