Mouse Gene Plin2 (ENSMUST00000000466.12) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Mus musculus perilipin 2 (Plin2), mRNA. (from RefSeq NM_007408)
Gencode Transcript: ENSMUST00000000466.12
Gencode Gene: ENSMUSG00000028494.12
Transcript (Including UTRs)
   Position: mm10 chr4:86,656,565-86,670,060 Size: 13,496 Total Exon Count: 8 Strand: -
Coding Region
   Position: mm10 chr4:86,657,033-86,668,679 Size: 11,647 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:86,656,565-86,670,060)mRNA (may differ from genome)Protein (425 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
PubMedSOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PLIN2_MOUSE
DESCRIPTION: RecName: Full=Perilipin-2; AltName: Full=Adipophilin; AltName: Full=Adipose differentiation-related protein; Short=ADRP;
FUNCTION: May be involved in development and maintenance of adipose tissue.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Adipose tissue specific. Expressed abundantly and preferentially in fat pads.
INDUCTION: By dexamethasone.
SIMILARITY: Belongs to the perilipin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.00142-0.317 Picture PostScript Text
3' UTR -144.60468-0.309 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004279 - Perilipin

Pfam Domains:
PF03036 - Perilipin family

SCOP Domains:
109775 - Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain

ModBase Predicted Comparative 3D Structure on P43883
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
GenBankRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0014070 response to organic cyclic compound
GO:0015909 long-chain fatty acid transport
GO:0019915 lipid storage
GO:0042493 response to drug

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK152877 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830089E01 product:adipose differentiation related protein, full insert sequence.
AK011014 - Mus musculus 13 days embryo liver cDNA, RIKEN full-length enriched library, clone:2510028E23 product:adipose differentiation related protein, full insert sequence.
AK090277 - Mus musculus adult male gall bladder cDNA, RIKEN full-length enriched library, clone:G630033C11 product:adipose differentiation related protein, full insert sequence.
AK002911 - Mus musculus adult male kidney cDNA, RIKEN full-length enriched library, clone:0610042H15 product:adipose differentiation related protein, full insert sequence.
AK154582 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630049D05 product:adipose differentiation related protein, full insert sequence.
AK152081 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830047F06 product:adipose differentiation related protein, full insert sequence.
AK152896 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830089J21 product:adipose differentiation related protein, full insert sequence.
BC047124 - Mus musculus adipose differentiation related protein, mRNA (cDNA clone IMAGE:5027325).
AK152263 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830057L15 product:adipose differentiation related protein, full insert sequence.
AK152982 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830097K16 product:adipose differentiation related protein, full insert sequence.
BC054766 - Mus musculus adipose differentiation related protein, mRNA (cDNA clone MGC:64802 IMAGE:6414796), complete cds.
AK153222 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830128C06 product:adipose differentiation related protein, full insert sequence.
AK078967 - Mus musculus adult male cecum cDNA, RIKEN full-length enriched library, clone:9130414H03 product:adipose differentiation related protein, full insert sequence.
AK150177 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:G530141O19 product:adipose differentiation related protein, full insert sequence.
AK167140 - Mus musculus blastocyst blastocyst cDNA, RIKEN full-length enriched library, clone:I1C0033N08 product:adipose differentiation related protein, full insert sequence.
M93275 - Mouse adipose differentiation related protein (ADFP) mRNA, complete cds.
AK181873 - Mus musculus cDNA, clone:Y0G0119N13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000000466, based on BLAT search.
AK188078 - Mus musculus cDNA, clone:Y0G0144A05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000000466, based on BLAT search.
LF194467 - JP 2014500723-A/1970: Polycomb-Associated Non-Coding RNAs.
AY035850 - Mus musculus C57BL/6J adipose differentiation-related protein mRNA, complete cds.
AY035851 - Mus musculus DBA/2J adipose differentiation-related protein mRNA, complete cds.
LF273118 - JP 2014500723-A/80621: Polycomb-Associated Non-Coding RNAs.
LF273119 - JP 2014500723-A/80622: Polycomb-Associated Non-Coding RNAs.
AK181807 - Mus musculus cDNA, clone:Y0G0119I05, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000000466, based on BLAT search.
AK192865 - Mus musculus cDNA, clone:Y1G0110D06, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000000466, based on BLAT search.
AK206949 - Mus musculus cDNA, clone:Y2G0106H11, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000000466, based on BLAT search.
AK186811 - Mus musculus cDNA, clone:Y0G0138N08, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000000466, based on BLAT search.
AK179029 - Mus musculus cDNA, clone:Y0G0108N16, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000000466, based on BLAT search.
MA430044 - JP 2018138019-A/1970: Polycomb-Associated Non-Coding RNAs.
MA508695 - JP 2018138019-A/80621: Polycomb-Associated Non-Coding RNAs.
MA508696 - JP 2018138019-A/80622: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: Adfp, Adrp, NM_007408, P43883, PLIN2_MOUSE, Q8K3Q8, uc008tlz.1, uc008tlz.2
UCSC ID: uc008tlz.2
RefSeq Accession: NM_007408
Protein: P43883 (aka PLIN2_MOUSE)
CCDS: CCDS18308.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.