Mouse Gene Dennd4c (ENSMUST00000082026.13) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin. (from UniProt A6H8H2)
Gencode Transcript: ENSMUST00000082026.13
Gencode Gene: ENSMUSG00000038024.17
Transcript (Including UTRs)
Position: mm10 chr4:86,748,555-86,850,603 Size: 102,049 Total Exon Count: 33 Strand: +
Coding Region
Position: mm10 chr4:86,774,255-86,848,906 Size: 74,652 Coding Exon Count: 32
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: DEN4C_MOUSE
DESCRIPTION: RecName: Full=DENN domain-containing protein 4C;
FUNCTION: Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane. Cell membrane. Cytoplasm, cytosol. Note=Associates with SLC2A4/GLUT4 storage vesicles.PTM: Phosphorylated in response to insulin.SIMILARITY: Contains 1 dDENN domain.SIMILARITY: Contains 1 DENN domain.SIMILARITY: Contains 1 MABP domain.SIMILARITY: Contains 1 PPR (pentatricopeptide) repeat.SIMILARITY: Contains 1 uDENN domain.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR005112 - dDENN_dom
IPR001194 - DENN_dom
IPR023341 - MABP
IPR005113 - uDENN_dom
Pfam Domains: PF02141 - DENN (AEX-3) domain
PF03455 - dDENN domain
PF03456 - uDENN domain
ModBase Predicted Comparative 3D Structure on A6H8H2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK155220 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630209B03 product:weakly similar to C-MYC promoter-binding protein IRLB [Homo sapiens], full insert sequence.AK154950 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630112K10 product:hypothetical protein, full insert sequence.BC146602 - Mus musculus DENN/MADD domain containing 4C, mRNA (cDNA clone MGC:144204 IMAGE:40099465), complete cds.AK158927 - Mus musculus visual cortex cDNA, RIKEN full-length enriched library, clone:K530010J07 product:hypothetical dDENN domain containing protein, full insert sequence.BC040249 - Mus musculus DENN/MADD domain containing 4C, mRNA (cDNA clone IMAGE:3991270), containing frame-shift errors.BC040798 - Mus musculus DENN/MADD domain containing 4C, mRNA (cDNA clone IMAGE:3991270), containing frame-shift errors.AK034073 - Mus musculus adult male diencephalon cDNA, RIKEN full-length enriched library, clone:9330154F04 product:unclassifiable, full insert sequence.AK155029 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630116O15 product:weakly similar to IRLB (Fragment) [Homo sapiens], full insert sequence.AK172154 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830048M24 product:hypothetical protein, full insert sequence.AK006885 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700065A05 product:unclassifiable, full insert sequence.AK018928 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:1700094P17 product:RIKEN cDNA 1700065A05 gene, full insert sequence.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A2AJX5, A6H8H2, BC146602, DEN4C_MOUSE, Q3U2K9, uc008tmc.1, uc008tmc.2, uc008tmc.3UCSC ID: uc008tmc.3RefSeq Accession: NM_184088
Protein: A6H8H2
(aka DEN4C_MOUSE)
CCDS: CCDS51218.2
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.