Mouse Gene Atp6v0b (ENSMUST00000036380.13) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus ATPase, H+ transporting, lysosomal V0 subunit B (Atp6v0b), mRNA. (from RefSeq NM_033617)
Gencode Transcript: ENSMUST00000036380.13
Gencode Gene: ENSMUSG00000033379.13
Transcript (Including UTRs)
Position: mm10 chr4:117,884,326-117,887,329 Size: 3,004 Total Exon Count: 8 Strand: -
Coding Region
Position: mm10 chr4:117,884,615-117,887,236 Size: 2,622 Coding Exon Count: 8
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: VATO_MOUSE
DESCRIPTION: RecName: Full=V-type proton ATPase 21 kDa proteolipid subunit; Short=V-ATPase 21 kDa proteolipid subunit; AltName: Full=23 kDa subunit of V-ATPase; AltName: Full=Vacuolar proton pump 21 kDa proteolipid subunit;
FUNCTION: Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.SUBUNIT: Interacts with IFITM3.SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Ubiquitous.SIMILARITY: Belongs to the V-ATPase proteolipid subunit family.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR002379 - ATPase_F0/V0-cplx_csu
IPR000245 - ATPase_V0-cplx_csu
Pfam Domains: PF00137 - ATP synthase subunit C
SCOP Domains: 81333 - F1F0 ATP synthase subunit C
ModBase Predicted Comparative 3D Structure on Q91V37
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process: GO:0006811 ion transport
GO:0007035 vacuolar acidification
GO:0015991 ATP hydrolysis coupled proton transport
Cellular Component: GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005768 endosome
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016471 vacuolar proton-transporting V-type ATPase complex
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179 proton-transporting V-type ATPase, V0 domain
Descriptions from all associated GenBank mRNAs
LF194567 - JP 2014500723-A/2070: Polycomb-Associated Non-Coding RNAs.LF194569 - JP 2014500723-A/2072: Polycomb-Associated Non-Coding RNAs.AK211031 - Mus musculus cDNA, clone:Y2G0120G22, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.AK211051 - Mus musculus cDNA, clone:Y2G0120H21, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.AK189647 - Mus musculus cDNA, clone:Y0G0149O07, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.BC030393 - Mus musculus ATPase, H+ transporting, lysosomal V0 subunit B, mRNA (cDNA clone MGC:40642 IMAGE:4922226), complete cds.LF274155 - JP 2014500723-A/81658: Polycomb-Associated Non-Coding RNAs.AK021272 - Mus musculus 12 days embryo spinal cord cDNA, RIKEN full-length enriched library, clone:C530010I21 product:ATPase, H+ transporting, lysosomal (vacuolar proton pump), full insert sequence.AK009495 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310024H13 product:ATPase, H+ transporting, lysosomal (vacuolar proton pump), full insert sequence.AK152823 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830086M23 product:ATPase, H+ transporting, V0 subunit B, full insert sequence.AF356006 - Mus musculus vacuolar proton-translocating ATPase 21 kDa subunit mRNA, complete cds.BC009169 - Mus musculus ATPase, H+ transporting, lysosomal V0 subunit B, mRNA (cDNA clone MGC:6568 IMAGE:2812497), complete cds.AB060654 - Mus musculus Atp6f mRNA for 23-kDa proteolipid, complete cds.AK151365 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830028J18 product:ATPase, H+ transporting, V0 subunit B, full insert sequence.AK151847 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830040I06 product:ATPase, H+ transporting, V0 subunit B, full insert sequence.AK170493 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630105L04 product:ATPase, H+ transporting, V0 subunit B, full insert sequence.AK152330 - Mus musculus bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830062H05 product:ATPase, H+ transporting, V0 subunit B, full insert sequence.AK210235 - Mus musculus cDNA, clone:Y2G0117L23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.AK212370 - Mus musculus cDNA, clone:Y2G0124L14, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.AK205813 - Mus musculus cDNA, clone:Y2G0102N20, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.AK206535 - Mus musculus cDNA, clone:Y2G0105C23, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.AK180083 - Mus musculus cDNA, clone:Y0G0112N13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.AK208636 - Mus musculus cDNA, clone:Y2G0112E11, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.LF274158 - JP 2014500723-A/81661: Polycomb-Associated Non-Coding RNAs.AK184951 - Mus musculus cDNA, clone:Y0G0132B10, strand:unspecified.BD062203 - Gene diagnostic agent/gene therapeutic agent of tumor using tumor specific antigen and novel application of proton pump inhibitor as antitumor drug.AK179535 - Mus musculus cDNA, clone:Y0G0110M14, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.AK200953 - Mus musculus cDNA, clone:Y1G0136I09, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.AK217120 - Mus musculus cDNA, clone:Y2G0140L13, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000036380, based on BLAT search.LF274162 - JP 2014500723-A/81665: Polycomb-Associated Non-Coding RNAs.MA430144 - JP 2018138019-A/2070: Polycomb-Associated Non-Coding RNAs.MA430146 - JP 2018138019-A/2072: Polycomb-Associated Non-Coding RNAs.MA509732 - JP 2018138019-A/81658: Polycomb-Associated Non-Coding RNAs.MA509735 - JP 2018138019-A/81661: Polycomb-Associated Non-Coding RNAs.MA509739 - JP 2018138019-A/81665: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: Atp6f, NM_033617, Q91V37, uc008ujc.1, uc008ujc.2, VATO_MOUSEUCSC ID: uc008ujc.2RefSeq Accession: NM_033617
Protein: Q91V37
(aka VATO_MOUSE)
CCDS: CCDS18540.1
Gene Model Information
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.