ID:PTPRF_MOUSE DESCRIPTION: RecName: Full=Receptor-type tyrosine-protein phosphatase F; EC=3.1.3.48; AltName: Full=Leukocyte common antigen related; Short=LAR; Flags: Precursor; FUNCTION: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) (By similarity). CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. SUBUNIT: Interacts with GRIP1 (By similarity). Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity). Interacts with PTPRF (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed in the cell of the T lineage but not in cells of any other hemopoietic lineage. DOMAIN: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one (By similarity). SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. SIMILARITY: Contains 8 fibronectin type-III domains. SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 2 tyrosine-protein phosphatase domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A2A8L5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.