ID:PP1R8_MOUSE DESCRIPTION: RecName: Full=Nuclear inhibitor of protein phosphatase 1; Short=NIPP-1; AltName: Full=Protein phosphatase 1 regulatory inhibitor subunit 8; FUNCTION: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development. SUBUNIT: Interacts with phosphorylated CDC5L, SF3B1 and MELK. Part of the spliceosome. Interacts with PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts with EED. Part of a complex consisting of PPP1R8, EED, HDAC2 and PP-1. SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus speckle (By similarity). Note=Mainly, but not exclusively, nuclear. DOMAIN: Has a basic N- and C-terminal and an acidic central domain. DOMAIN: The FHA domain mediates interactions with threonine- phosphorylated MELK. PTM: May be inactivated by phosphorylation on Ser-199 or Ser-204 (By similarity). DISRUPTION PHENOTYPE: Mice display a retarded growth and embryonic lethality at E6.5, due to defects in proliferation rate. SIMILARITY: Contains 1 FHA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8R3G1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
