ID:ESPN_MOUSE DESCRIPTION: RecName: Full=Espin; AltName: Full=Ectoplasmic specialization protein; FUNCTION: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells. SUBUNIT: Monomer. Binds F-actin in a Ca(2+)-resistant fashion. Interacts (via N-terminal) with BAIAP2 (via SH3-domain). Interacts with PFN2. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, stereocilium. Cell projection, microvillus. Cell junction. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, cytoskeleton. Cell projection, dendritic spine. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, cytoskeleton. Cell projection, dendritic spine. SUBCELLULAR LOCATION: Isoform 4: Cytoplasm, cytoskeleton. Cell projection, dendritic spine. SUBCELLULAR LOCATION: Isoform 5: Cytoplasm, cytoskeleton. Cell projection, dendritic spine. SUBCELLULAR LOCATION: Isoform 8: Cytoplasm, cytoskeleton. Cell junction. Note=Isoform 8 localizes to parallel actin bundles of ectoplasmic specializations between neighboring Sertoli cells and at sites where Sertoli cells contact the heads of elongate spermatids. TISSUE SPECIFICITY: Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells. Isoforms 2, 3, 4 and 5 are expressed in Purkinje cells dentritic spines. DOMAIN: The WH2-domain binds actin monomer and mediates actin bundle assembly. MISCELLANEOUS: Jerker mice has a frameshift mutation that affect the espin C-terminus. This mutation cause deafness, vestibular dysfunction and hair cell degeneration. SIMILARITY: Contains 9 ANK repeats. SIMILARITY: Contains 1 WH2 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ET47
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
