Mouse Gene Hgf (ENSMUST00000199581.4) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus hepatocyte growth factor (Hgf), transcript variant 3, mRNA. (from RefSeq NM_010427) RefSeq Summary (NM_010427): This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]. Gencode Transcript: ENSMUST00000199581.4 Gencode Gene: ENSMUSG00000028864.7 Transcript (Including UTRs) Position: mm10 chr5:16,553,550-16,620,152 Size: 66,603 Total Exon Count: 19 Strand: + Coding Region Position: mm10 chr5:16,553,928-16,618,993 Size: 65,066 Coding Exon Count: 18
ID:HGF_MOUSE DESCRIPTION: RecName: Full=Hepatocyte growth factor; AltName: Full=Hepatopoietin-A; AltName: Full=Scatter factor; Short=SF; Contains: RecName: Full=Hepatocyte growth factor alpha chain; Contains: RecName: Full=Hepatocyte growth factor beta chain; Flags: Precursor; FUNCTION: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization. SUBUNIT: Dimer of an alpha chain and a beta chain linked by a disulfide bond. SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily. SIMILARITY: Contains 4 kringle domains. SIMILARITY: Contains 1 PAN domain. SIMILARITY: Contains 1 peptidase S1 domain. SEQUENCE CAUTION: Sequence=CAA51054.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q08048
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004252 serine-type endopeptidase activity GO:0005515 protein binding GO:0008083 growth factor activity GO:0042056 chemoattractant activity GO:0042802 identical protein binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0000187 activation of MAPK activity GO:0000902 cell morphogenesis GO:0001889 liver development GO:0006508 proteolysis GO:0008283 cell proliferation GO:0008284 positive regulation of cell proliferation GO:0010469 regulation of receptor activity GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0030212 hyaluronan metabolic process GO:0030335 positive regulation of cell migration GO:0031100 animal organ regeneration GO:0031643 positive regulation of myelination GO:0032715 negative regulation of interleukin-6 production GO:0032733 positive regulation of interleukin-10 production GO:0033137 negative regulation of peptidyl-serine phosphorylation GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045766 positive regulation of angiogenesis GO:0048012 hepatocyte growth factor receptor signaling pathway GO:0050728 negative regulation of inflammatory response GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050918 positive chemotaxis GO:0051450 myoblast proliferation GO:0060326 cell chemotaxis GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0070572 positive regulation of neuron projection regeneration GO:0090201 negative regulation of release of cytochrome c from mitochondria GO:1900744 regulation of p38MAPK cascade GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902947 regulation of tau-protein kinase activity GO:2000573 positive regulation of DNA biosynthetic process
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space