Mouse Gene Cad (ENSMUST00000013773.11) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Mus musculus carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (Cad), transcript variant 1, mRNA. (from RefSeq NM_023525)
Gencode Transcript: ENSMUST00000013773.11
Gencode Gene: ENSMUSG00000013629.16
Transcript (Including UTRs)
Position: mm10 chr5:31,054,780-31,078,479 Size: 23,700 Total Exon Count: 44 Strand: +
Coding Region
Position: mm10 chr5:31,054,955-31,078,195 Size: 23,241 Coding Exon Count: 44
Data last updated at UCSC: 2019-09-19
Sequence and Links to Tools and Databases
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR006132 - Asp/Orn_carbamoyltranf_P-bd
IPR006130 - Asp/Orn_carbamoylTrfase
IPR002082 - Asp_carbamoyltransf
IPR006131 - Asp_carbamoyltransf_Asp/Orn-bd
IPR011761 - ATP-grasp
IPR013815 - ATP_grasp_subdomain_1
IPR013816 - ATP_grasp_subdomain_2
IPR006275 - CarbamoylP_synth_lsu
IPR005481 - CarbamoylP_synth_lsu_N
IPR005480 - CarbamoylP_synth_lsu_oligo
IPR006274 - CarbamoylP_synth_ssu
IPR002474 - CarbamoylP_synth_ssu_N
IPR005479 - CbamoylP_synth_lsu-like_ATP-bd
IPR005483 - CbamoylP_synth_lsu_CPSase_dom
IPR002195 - Dihydroorotase_CS
IPR017926 - GATASE_1
IPR011059 - Metal-dep_hydrolase_composite
IPR011607 - MGS-like_dom
IPR016185 - PreATP-grasp_fold
Pfam Domains: PF00117 - Glutamine amidotransferase class-I
PF00185 - Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
PF00988 - Carbamoyl-phosphate synthase small chain, CPSase domain
PF01979 - Amidohydrolase family
PF02142 - MGS-like domain
PF02222 - ATP-grasp domain
PF02729 - Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
PF02786 - Carbamoyl-phosphate synthase L chain, ATP binding domain
PF02787 - Carbamoyl-phosphate synthetase large chain, oligomerisation domain
PF07478 - D-ala D-ala ligase C-terminus
SCOP Domains: 48108 - Carbamoyl phosphate synthetase, large subunit connection domain
51338 - Composite domain of metallo-dependent hydrolases
51556 - Metallo-dependent hydrolases
51735 - NAD(P)-binding Rossmann-fold domains
52317 - Class I glutamine amidotransferase-like
52335 - Methylglyoxal synthase-like
52440 - PreATP-grasp domain
51984 - MurCD N-terminal domain
53671 - Aspartate/ornithine carbamoyltransferase
52021 - Carbamoyl phosphate synthetase, small subunit N-terminal domain
56059 - Glutathione synthetase ATP-binding domain-like
ModBase Predicted Comparative 3D Structure on B2RQC6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC053097 - Mus musculus carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, mRNA (cDNA clone IMAGE:6401499), partial cds.BC060119 - Mus musculus cDNA clone IMAGE:6412771, containing frame-shift errors.BC137856 - Mus musculus carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, mRNA (cDNA clone MGC:169480 IMAGE:8860875), complete cds.BC144972 - Mus musculus carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, mRNA (cDNA clone MGC:178528 IMAGE:9053520), complete cds.BC144973 - Mus musculus cDNA clone IMAGE:9053521, containing frame-shift errors.BC060717 - Mus musculus carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, mRNA (cDNA clone IMAGE:6405535), partial cds.BC043325 - Mus musculus carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, mRNA (cDNA clone IMAGE:5373003), partial cds.BC026620 - Mus musculus carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase, mRNA (cDNA clone IMAGE:4977352), with apparent retained intron.AK010453 - Mus musculus ES cells cDNA, RIKEN full-length enriched library, clone:2410008J01 product:pyrimidine synthesis protein CAD (fragment) homolog [Homo sapiens], full insert sequence.AF053339 - Mus musculus aspartate transcarbamylase mRNA, partial cds.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes mmu00240 - Pyrimidine metabolismmmu00250 - Alanine, aspartate and glutamate metabolismmmu01100 - Metabolic pathways
BioCyc Knowledge Library PWY-5686 - uridine-5'-phosphate biosynthesis
PWY0-162 - pyrimidine ribonucleotides de novo biosynthesis
Reactome (by CSHL, EBI, and GO) Protein B2RQC6 (Reactome details) participates in the following event(s):R-MMU-73571 N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O
R-MMU-73573 carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate
R-MMU-73577 L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate
R-MMU-500753 Pyrimidine biosynthesis
R-MMU-8956320 Nucleobase biosynthesis
R-MMU-15869 Metabolism of nucleotides
R-MMU-1430728 Metabolism
Other Names for This Gene
Gene Model Information
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Methods, Credits, and Use Restrictions
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